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胱天蛋白酶3(CASP3)活性蛋白

Active Caspase 3 (CASP3)

CPP32; CPP32B; SCA1; Apoptain; Yama; Apoptosis-Related Cysteine Peptidase; Cysteinyl Aspartate Specific Proteinases 3; SREBP cleavage activity 1

  • 胱天蛋白酶3(CASP3)活性蛋白 产品包装(模拟)
  • 胱天蛋白酶3(CASP3)活性蛋白 产品包装(模拟)
  • APA626Hu01.png Figure. SDS-PAGE
  • Certificate 通过ISO 9001、ISO 13485质量体系认证

活性实验

Caspase 3 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6 and 7; and the protein itself is processed and activated by caspases 8, 9, and 10. Caspase 3 can hydrolyze the peptide substrate acetyl-Asp-Glu-Val-Asp-p-nitroanilide (Ac-DEVD-pNA) resulting in the release of the p-nitroaniline (pNA) moiety. p-Nitroaniline has a high absorbance at 405nm. Thus the activity of recombinant human caspase 3 can be measured by calculate the concentration of the pNA released from the substrate. The reaction was performed in adding 50μL 2×buffer (50mM HEPES, 100mM NaCl, 10mM DTT, 2mM EDTA, 10% glycerol) to 96 well plates, then add 50μL various concentration of caspe 3 (diluted by 1×buffer, 25mM HEPES, 50mM NaCl, 5mM DTT, 1mM EDTA, 5% glycerol) to each well, finally, add 5μL 4mmol Ac-DEVD-pNA to each well. Cover the 96 well plates and incubate at 37℃ for 2h. p-Nitroaniline (pNA) standard curve prepare by double dilute 200μM pNA with 1×buffer and record the OD value at 405nm. Calculate the caspase 3 activity in pmol of pNA released per min per μg recombinat human caspase 3.
The specific activity of recombinant human caspase 3 is 2196pmol/min/μg.

用法

Reconstitute in ddH2O to a concentration ≤0.1mg/mL. Do not vortex.

储存

避免反复冻融。2-8°C不超过一个月,-80°C不超过12个月。

稳定性

热稳定性以损失率显示。损失率是由加速降解试验决定,具体方法如下:在37°C孵育48小时,没有显著的降解或者沉淀产生。保质期内,在适当的条件下存储,损失率低于5%。

相关产品

编号 适用物种:Homo sapiens (Human,人) 应用(仅供研究使用,不用于临床诊断!)
APA626Hu01 胱天蛋白酶3(CASP3)活性蛋白 Cell culture; Activity Assays.
RPA626Hu01 胱天蛋白酶3(CASP3)重组蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
RPA626Hu02 胱天蛋白酶3(CASP3)重组蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
RPA626Hu03 胱天蛋白酶3(CASP3)重组蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
PAA626Hu03 胱天蛋白酶3(CASP3)多克隆抗体 WB; IHC; ICC; IP.
PAA626Hu02 胱天蛋白酶3(CASP3)多克隆抗体 WB,IHC
PAA626Hu01 胱天蛋白酶3(CASP3)多克隆抗体 WB; IHC; ICC; IP.
LAA626Hu81 胱天蛋白酶3(CASP3)多克隆抗体(异硫氰酸荧光素标记) WB; IHC; ICC; IF.
LAA626Hu71 胱天蛋白酶3(CASP3)多克隆抗体(生物素标记) WB; IHC; ICC.
MAA626Hu21 胱天蛋白酶3(CASP3)单克隆抗体 WB; IHC; ICC; IP.
MAA626Hu22 胱天蛋白酶3(CASP3)单克隆抗体 WB; IHC; ICC; IP.
SEA626Hu 胱天蛋白酶3(CASP3)检测试剂盒(酶联免疫吸附试验法) Enzyme-linked immunosorbent assay for Antigen Detection.
LMA626Hu 胱天蛋白酶3(CASP3)等多因子检测试剂盒(流式荧光发光法) FLIA Kit for Antigen Detection.
KSA626Hu01 胱天蛋白酶3(CASP3)检测试剂盒DIY材料(酶联免疫吸附试验法) Main materials for "Do It (ELISA Kit) Yourself".

参考文献

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Life Sciences Malaysian propolis, metformin and their combination, exert hepatoprotective effect in streptozotocin-induced diabetic rats [Pubmed: 30205096]
AAPS PharmSciTech Augmentation of Fluvastatin Cytotoxicity Against Prostate Carcinoma PC3 Cell Line Utilizing Alpha Lipoic–Ellagic Acid Nanostructured Lipid Carrier Formula [Pubmed: 30350252]
Naunyn-Schmiedeberg's Archives of Pharmacology Side effects of frequently used oral antidiabetics on wound healing in vitro [Pubmed: 30535571]
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Acta Biochimica et Biophysica Sinica Adiponectin attenuates lipopolysaccharide-induced cell injury of H9c2 cells by regulating AMPK pathway [Pubmed: 30668810]
Food and Chemical Toxicology Gum Acacia mitigates diclofenac nephrotoxicity by targeting monocyte chemoattractant protein-1, complement receptor-1 and pro-apoptotic pathways [Pubmed: 31042592]
Environmental Toxicology Antihepatocarcinogenic activity of whey protein concentrate and lactoferrin in diethylnitrosamine‐treated male albino mice [Pubmed: 31087429]
Biological trace element research High Concentrations of Boric Acid Trigger Concentration-Dependent Oxidative Stress, Apoptotic Pathways and Morphological Alterations in DU-145 Human Prostate … [Pubmed: 31066018]
Skin pharmacology and physiology Side Effects of Frequently Used Antihypertensive Drugs on Wound Healing in vitro [Pubmed: 31018213]
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Cell Stress Chaperones Betaine suppresses cell proliferation by increasing oxidative stress–mediated apoptosis and inflammation in DU-145 human prostate cancer cell line [Pubmed: 31368044]
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Biological trace element research Concentration-Dependent Effects of Zinc Sulfate on DU-145 Human Prostate Cancer Cell Line: Oxidative, Apoptotic, Inflammatory, and Morphological Analyzes [Pubmed: 31463762]
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Pharmaceutics Chitosan-Based Microparticles Enhance Ellagic Acid's Colon Targeting and Proapoptotic Activity [Pubmed: 32660035]
Life Sciences Curcumin and LOXblock-1 ameliorate ischemia-reperfusion induced inflammation and acute kidney injury by suppressing the semaphorin-plexin pathway. [Pubmed: 32603817]
TOXICOLOGY Tert-butylhydroquinone preserve testicular steroidogenesis and spermatogenesis in cisplatin-intoxicated rats by targeting oxidative stress, inflammation and apoptosis [Pubmed: 32565124]
International Journal of Molecular Sciences Optimized Conjugation of Fluvastatin to HIV-1 TAT Displays Enhanced Pro-Apoptotic Activity in HepG2 Cells [Pubmed: 32531976]
analytical chemistry Fast Activation and Tracing of Caspase-3 Involved Cell Apoptosis by Combined Electrostimulation and Smart Signal-Amplified SERS Nanoprobes [Pubmed: 32395992]
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Iranian Journal of Basic Medical Sciences Chromon-3-aldehyde derivatives restore mitochondrial function in rat cerebral ischemia [Pubmed: 32963739]
International Journal of Research in Pharmaceutical In situ gel loaded with curcumin-based fluvastatin nanostructured carrier effective against squamous tongue carcinoma []
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Bangladesh Journal of Pharmacology Ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscerate improve mitochondrial function under condition of cerebral ischemia in rat []
International Journal of Pharmacology Ellagic Acid Loaded TPGS Micelles for Enhanced Anticancer Activities in Ovarian Cancer []
Strawberry (Fragaria x ananassa) leaf extract reduces brain damage in diabetic male rats []
Indian Journal of Animal Research Accacia senegel extract ameliorates Lead Acetate-mediated Hepatotoxicity in rats. []
RESEARCH SQUARE Experimental Observation of the Sequence of Tibial Plateau Chondrocyte and Matrix Degeneration in Spontaneous Osteoarthritis in Guinea Pigs []
Egyptian Journal of Basic and Applied Sciences Fish-oil supplementation improves retinal injury induced by diabetes and hypercholesterolemia in male Wistar rats []
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Norwegian Journal of development of the International Science CLINICAL AND PATHOGENETIC SIGNIFICANCE OF CHANGES IN PURINE METABOLISM DURING LUNG CANCER []
J Biochem Mol Toxicol Concanavalin A induces apoptosis in a dose©\dependent manner by modulating thiol/disulfide homeostasis in C6 glioblastoma cells [33604990]
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Sci Rep Tert-butylhydroquinone attenuates doxorubicin-induced dysregulation of testicular cytoprotective and steroidogenic genes, and improves spermatogenesis in rats [33750916]
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Environ Sci Pollut Res Int Comparative effects of metformin and Cistus laurifolius L. extract in streptozotocin-induced diabetic rat model: oxidative, inflammatory, apoptotic, and histopathological?¡­ [34097215]
Piceatannol Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by Modulation of Nrf2/HO-1/NF¦ÊB Axis. Front. Pharmacol. 11: 614897. doi?¡­ [33519479]
Biomed Pharmacother Allicin ameliorates renal ischemia/reperfusion injury via inhibition of oxidative stress and inflammation in rats [34426252]
Chem Biol Interact Protective role of naringin loaded solid nanoparticles against aflatoxin B1 induced hepatocellular carcinoma [34717916]
Biochim Biophys Acta Gen Subj Paraoxonase 2 protects against the CML mediated mitochondrial dysfunction through modulating JNK pathway in human retinal cells [34710487]
AAPS PharmSciTech Development of an Icariin-Loaded Bilosome-Melittin Formulation with Improved Anticancer Activity against Cancerous Pancreatic Cells [34668089]
Analytical Cellular Pathology The Synergistic Effect of TRPV1 on Oxidative Stress-Induced Autophagy and Apoptosis in Microglia [34336554]
Ecotoxicol Environ Saf Evaluation of cytogenotoxic potential and embryotoxicity of KRS-Cauvery River water in zebrafish (Danio rerio) [Pubmed:35183813]
Environ Sci Pollut Res Int Chrysin attenuates estradiol-induced endometrial hyperplasia in rats via enhancing PPARα activity [Pubmed:35301625]
PLoS One Neuroprotective effect of sodium alginate against chromium-induced brain damage in rats [Pubmed:35421180]
Journal of Ethnopharmacology Ethnopharmacological impact of Melaleuca rugulosa (Link) Craven leaves extract on liver inflammation [Pubmed:35337921]
Eur J Pharmacol Harmine prevents 3-nitropropionic acid-induced neurotoxicity in rats via enhancing NRF2-mediated signaling: Involvement of p21 and AMPK [Pubmed:35623405]
Gels QbD Supported Optimization of the Alginate-Chitosan Nanoparticles of Simvastatin in Enhancing the Anti-Proliferative Activity against Tongue Carcinoma [Pubmed:35200484]
Naunyn-Schmiedeberg's Archives Inflammatory Modulation of miR-155 Inhibits Doxorubicin‑Induced Testicular Dysfunction Via Sirt1/Foxo1 Pathway: Insight to the Role of Acacetin and Bacillus … [Pubmed:35715546]
Antioxidants Therapeutic Effects of Bee Bread on Obesity-Induced Testicular-Derived Oxidative Stress, Inflammation, and Apoptosis in High-Fat Diet Obese Rat Model … [Pubmed:35204140]
Value Health Sci Oksidatif, Apoptotik ve İnflamatuar Sinyal Yolakları üzerinden C6 Glioblastoma Hücrelerindeki ML351'in Antiproliferatif Etkileri []
Impact de l'incorporation d'acides gras à chaine moyenne, de suppléments de levures et d'avoine nue sur la santé intestinale ainsi que sur la consommation … []
Biointerface Research in Applied Chemistry Promising Therapeutic Efficacy of Trigonella-foenum graecum and Bone Marrow-Derived Mesenchymal Stem Cells on Skeletal Muscle Atrophy in Experimental … []
Arab Journal of Nuclear Sciences and Applications Potential activity of silver/hydroxyapatite nano composite against damaged liver consequence to irradiation []
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