转化生长因子β1(TGFb1)等多因子检测试剂盒(流式荧光发光法)
Multiplex Assay Kit for Transforming Growth Factor Beta 1 (TGFb1) ,etc. by FLIA (Flow Luminescence Immunoassay)
TGF-B1; CED; DPD1; LAP; Camurati-Engelmann Disease; Latency-associated peptide
（注：单次混测多因子不超过8个指标 ）
- 编号LMA124Ra
- 物种Rattus norvegicus (Rat，大鼠) 相同的名称，不同的物种。
- 实验方法双抗夹心
- 反应时长3.5h
- 检测范围0.98-1000pg/mL
- 灵敏度最小可检测剂量小于等于0.327 pg/mL.
- 样本类型serum, platelet-poor plasma, tissue homogenates, cell culture supernates and other biological fluids
- 下载 英文说明书 中文说明书
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通过ISO 9001、ISO 13485质量体系认证
特异性
本试剂盒用于检测转化生长因子β1(TGFb1)等多因子检测试剂盒(流式荧光发光法)，经检测与其它相似物质无明显交叉反应。
由于受到技术及样本来源的限制，不可能完成对所有相关或相似物质交叉反应检测，因此本试剂盒有可能与未经检测的其它物质有交叉反应。
回收率
分别于定值血清及血浆样本中加入一定量的转化生长因子β1(TGFb1)等多因子检测试剂盒(流式荧光发光法)（加标样品），重复测定并计算其均值，回收率为测定值与理论值的比率。
| 样本 | 回收率范围(%) | 平均回收率(%) |
| serum(n=5) | 80-96 | 91 |
| EDTA plasma(n=5) | 91-105 | 99 |
| heparin plasma(n=5) | 84-98 | 93 |
精密度
精密度用样品测定值的变异系数CV表示。CV(%) = SD/mean×100
批内差：取同批次试剂盒对低、中、高值定值样本进行定量检测,每份样本连续测定20 次，分别计算不同浓度样本的平均值及SD值。
批间差：选取3个不同批次的试剂盒分别对低、中、高值定值样本进行定量测定，每个样本使用同一试剂盒重复测定8次，分别计算不同浓度样本的平均值及SD值。
批内差： CV<10%
批间差： CV<12%
线性
在定值血清及血浆样本内加入适量的转化生长因子β1(TGFb1)等多因子检测试剂盒(流式荧光发光法)，并倍比稀释成1:2，1:4，1:8，1:16的待测样本，线性范围即为稀释后样本中转化生长因子β1(TGFb1)等多因子检测试剂盒(流式荧光发光法)含量的测定值与理论值的比率。
| 样本 | 1:2 | 1:4 | 1:8 | 1:16 |
| serum(n=5) | 85-102% | 80-102% | 85-99% | 84-99% |
| EDTA plasma(n=5) | 86-101% | 80-91% | 98-105% | 97-104% |
| heparin plasma(n=5) | 91-102% | 93-105% | 78-105% | 81-97% |
稳定性
经测定，试剂盒在有效期内按推荐温度保存，其活性降低率小于5%。
为减小外部因素对试剂盒破坏前后检测值的影响，实验室的环境条件需尽量保持一致，尤其是实验室内温度、湿度及温育条件。其次由同一实验员来进行操作可减少人为误差。
实验流程
1. 实验前标准品、试剂及样本准备；
2. 加样（标准品、样本、磁珠）标准品或样本100μL及磁珠10μL，
37°C酶标板振荡器孵育90分钟；
3. 磁吸甩干，加检测溶液A100μL，37°C酶标板振荡器孵育60分钟；
4. 磁吸洗板3次；
5. 加检测溶液B100μL，37°C振动孵育30分钟；
6. 磁吸洗板3次；
7. 加鞘液100μL，旋涡震荡2分钟后读数。
实验原理
将转化生长因子β1(TGFb1)等多因子检测试剂盒(流式荧光发光法)抗体包被于磁珠，制成固相载体，向微孔中分别加入标准品或标本以及磁珠，其中的转化生长因子β1(TGFb1)等多因子检测试剂盒(流式荧光发光法)与连接于固相载体上的抗体结合，然后加入生物素化的转化生长因子β1(TGFb1)等多因子检测试剂盒(流式荧光发光法)抗体，将未结合的生物素化抗体洗净后，加入PE标记的亲和素，再次彻底洗涤后即可上机读数。MFI值和样品中的转化生长因子β1(TGFb1)等多因子检测试剂盒(流式荧光发光法)呈正相关。
赠品
增值服务
相关产品
| 编号 | 适用物种：Rattus norvegicus (Rat，大鼠) | 应用(仅供研究使用，不用于临床诊断！) |
| RPA124Ra01 | 转化生长因子β1(TGFb1)重组蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA124Ra01 | 转化生长因子β1(TGFb1)活性蛋白 | Cell culture; Activity Assays. |
| PAA124Ra01 | 转化生长因子β1(TGFb1)多克隆抗体 | WB; IHC; ICC; IP. |
| LAA124Ra81 | 转化生长因子β1(TGFb1)多克隆抗体(异硫氰酸荧光素标记) | WB; IHC; ICC; IF. |
| LAA124Ra71 | 转化生长因子β1(TGFb1)多克隆抗体(生物素标记) | WB; IHC; ICC. |
| MAA124Ra22 | 转化生长因子β1(TGFb1)单克隆抗体 | WB; IHC; ICC; IP. |
| MAA124Ra23 | 转化生长因子β1(TGFb1)单克隆抗体 | WB; IHC; ICC; IP. |
| MAA124Ra24 | 转化生长因子β1(TGFb1)单克隆抗体 | WB; IHC; ICC; IP. |
| MAA124Ra21 | 转化生长因子β1(TGFb1)单克隆抗体 | WB; IHC; ICC; IP. |
| MAA124Ra25 | 转化生长因子β1(TGFb1)单克隆抗体 | WB; IHC; ICC; IP. |
| SEA124Ra | 转化生长因子β1(TGFb1)检测试剂盒(酶联免疫吸附试验法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA124Ra | 转化生长因子β1(TGFb1)检测试剂盒(化学发光免疫分析法) | Chemiluminescent immunoassay for Antigen Detection. |
| LMA124Ra | 转化生长因子β1(TGFb1)等多因子检测试剂盒(流式荧光发光法) | FLIA Kit for Antigen Detection. |
| KSA124Ra01 | 转化生长因子β1(TGFb1)检测试剂盒DIY材料(酶联免疫吸附试验法) | Main materials for "Do It (ELISA Kit) Yourself". |
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| Cell Communication and Signaling | Rapamycin promotes endothelial–mesenchymal transition during stress-induced premature senescence through the activation of autophagy [Pubmed: 32164764] |
| Biomed Pharmacother | Soufeng Yuchuan decoction mitigates the ovalbumin-induced lung damage in a rat model of asthma [Pubmed: 32036215] |
| Biochemical and Biophysical Research Communications | Isorhynchophylline exerts anti-asthma effects in mice by inhibiting the proliferation of airway smooth muscle cells: The involvement of miR-200a-mediated FOXC1/NF … [Pubmed: 31733831] |
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | Vitamin D Attenuates Loss of Endothelial Biomarker Expression in Cardio-Endothelial Cells [Pubmed: 32235811] |
| Journal of Oral Biology and Craniofacial Research | Levels of TGF-β1 in peri-miniscrew implant crevicular fluid [Pubmed: 32211284] |
| Acta Histochem | Paeoniflorin accelerates foot wound healing in diabetic rats though activating the Nrf2 pathway [Pubmed: 33166863] |
| EUROPEAN JOURNAL OF PHARMACOLOGY | The anti-asthmatic potential of flavonol kaempferol in an experimental model of allergic airway inflammation [Pubmed: 33122672] |
| Journal of Cosmetic Dermatology | Examination of androgenetic alopecia with serum biomarkers [Pubmed: 32969583] |
| MOLECULAR AND CELLULAR BIOCHEMISTRY | Soluble recombinant human thrombomodulin suppresses inflammation-induced gastrointestinal tumor growth in a murine peritonitis model [Pubmed: 32767229] |
| CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | Hepatoprotective effect of Linagliptin against liver fibrosis induced by carbon tetrachloride in mice [Pubmed: 32726558] |
| EXPERIMENTAL DERMATOLOGY | Decreased suppression of CD8+ and CD4+ T cells by peripheral Regulatory T cells in Generalized Vitiligo due to reduced NFATC1 and FOXP3 proteins [Pubmed: 32682346] |
| Scientific Reports | Erlotinib can halt adenine induced nephrotoxicity in mice through modulating ERK1/2, STAT3, p53 and apoptotic pathways [Pubmed: 32661331] |
| international journal of biological macromolecules | Chlorella vulgaris α-L-arabino-α-L-rhamno-α, β-D-galactan structure and mechanisms of its anti-inflammatory and anti-remodelling effects [Pubmed: 32565301] |
| Exp Cell Res | Exosomal miR-532–5p from bone marrow mesenchymal stem cells reduce intervertebral disc degeneration by targeting RASSF5 [Pubmed: 32464126] |
| JOURNAL OF IMMUNOLOGY RESEARCH | The Sufficient Immunoregulatory Effect of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation on Regulatory T Cells in Patients with … [Pubmed: 32411794] |
| Frontiers in Pharmacology | M10, a Myricetin-3-ObD-Lactose Sodium Salt, Prevents Ulcerative Colitis Through Inhibiting Necroptosis in Mice [Pubmed: 33041798] |
| Food & Function | Nicotinamide riboside alleviates alcohol-induced depression-like behaviours in C57BL/6J mice by altering the intestinal microbiota associated with microglial … [] |
| Effect of metformin and indole-3-carbinol on a rat model of Parkinson's disease induced by 6-hydroxydopamine [] | |
| Research square | Vitamin D Status in Dupuytren's Disease: Association with Clinical Status and Vitamin D Receptor Expression [] |
| Phytomedicine | Menthacarin attenuates experimental colitis [] |
| Immunomodulatory effects of sCD83 via induction of TGF-β1 and IDO: an in vitro and rat orthotopic liver transplantation study [] | |
| BMC Complement Med Ther | Suppression of autophagy through JAK2/STAT3 contributes to the therapeutic action of rhynchophylline on asthma [33413331] |
| Life Sci | Celecoxib ameliorates liver cirrhosis via reducing inflammation and oxidative stress along spleen-liver axis in rats [33577848] |
| CLINICAL SCIENCE | Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes [33491733] |
| Bioact Mater | New design to remove leukocytes from platelet-rich plasma (PRP) based on cell dimension rather than density [33842739] |
| Acta Biomater | Highly interconnected inverse opal extracellular matrix scaffolds enhance stem cell therapy in limb ischemia [33878473] |
| Mol Cell Biochem | Human umbilical cord-derived mesenchymal stem cells and their chondroprogenitor derivatives reduced pain and inflammation signaling and promote regeneration in?¡ [33864569] |
| Cell Death & Disease | Sodium/glucose cotransporter 1-dependent metabolic alterations induce tamoxifen resistance in breast cancer by promoting macrophage M2 polarization [34006822] |
| PLoS One | Beneficial impact of cathelicidin on hypersensitivity pneumonitis treatment¡ªIn vivo studies [33999928] |
| Vascular pharmacology | Nectin-4 promotes lymphangiogenesis and lymphatic metastasis in breast cancer by regulating CXCR4-LYVE1 axis [33945869] |
| Equine Vet J | Limited added value of negative pressure wound therapy compared to calcium alginate dressings for second intention healing in a non©\contaminated and?¡ [34115409] |
| Stem Cells International | The Paracrine Effect of Adipose-Derived Stem Cells Orchestrates Competition between Different Damaged Dermal Fibroblasts to Repair UVB-Induced Skin?¡ [33381190] |
| Journal of Pharmacy and Pharmacology | Pharmacodynamic evaluation of dihydroxyflavone derivate chrysin in a guinea pig model of allergic asthma [33793800] |
| Bull. Egypt. Soc. Physiol. Sci. | Flaxseed Oil Supplementation Afford Comparable Therapeutic effect to Metformin in Bleomycin Induced Pulmonary Fibrosis Rat model [] |
| У¿¯ | Role of Angiotensin II and Renal Nerves on TGF-b/SmadPathway in Diabetic Nephropathy Rat Model [] |
| Bioactive Materials | Calcium phosphate-based materials regulate osteoclast-mediated osseointegration [] |
| Mediators of Inflammation | Sparstolonin B Exerts Therapeutic Effects on Collagen-Induced Arthritis by Inhibiting the NLRP3 Inflammasome and Reducing the Activity of ¦Á1, 3 ¡ [] |
| Manuscript title Microparticles Containing MiR-625-5p In Coronary Artery Reduce Myocardial Fibrosis After Myocardial Infarction [] | |
| Andrology | X‐ray micro‐computed tomography in the assessment of penile cavernous fibrosis in a rabbit castration model [34236146] |
| Aging | Yiqi Jiemin decoction alleviates allergic rhinitis in a guinea pig model by suppressing inflammation, restoring Th1/Th2 balance, and improving cellular … [34315133] |
| Tissue Eng Regen Med | Effect of Leukocyte-Platelet Rich Fibrin (L-PRF) on Tissue Regeneration and Proliferation of Human Gingival Fibroblast Cells Cultured Using a Modified Method [34339025] |
| Am J Transl Res | Wuling San and Xiao Chaihu Decoction affect airway inflammatory response and airway smooth muscle cell proliferation in mice with allergic asthma via miR … [34786062] |
| Biomacromolecules | In Situ Forming Cellulose Nanofibril-Reinforced Hyaluronic Acid Hydrogel for Cartilage Regeneration [34723499] |
| Brain Sci | Neuroprotective Effect of Clobenpropit against Lipopolysaccharide-Induced Cognitive Deficits via Attenuating Neuroinflammation and Enhancing Mitochondrial … [34942919] |
| Biomedicines | Exploring Epithelial–Mesenchymal Transition Signals in Endometriosis Diagnosis and In Vitro Fertilization Outcomes [34829910] |
| J Inflamm Res | Clenbuterol, a Selective β2-Adrenergic Receptor Agonist, Inhibits or Limits Post-Stroke Pneumonia, but Increases Infarct Volume in MCAO Mice [Pubmed:35058704] |
| Cancer Commun (Lond) | Anti‐PD‐L1/TGF‐βR fusion protein (SHR‐1701) overcomes disrupted lymphocyte recovery‐induced resistance to PD‐1/PD‐L1 inhibitors in lung cancer [Pubmed:34981670] |
| Polymers (Basel) | 3D Printed Scaffold Based on Type I Collagen/PLGA_TGF-β1 Nanoparticles Mimicking the Growth Factor Footprint of Human Bone Tissue [Pubmed:35267680] |
| Biomed Pharmacother | Jiangu granule ameliorated OVX rats bone loss by modulating gut microbiota-SCFAs-Treg/Th17 axis [Pubmed:35453007] |
| Biomed Pharmacother | Huangbai liniment and berberine promoted wound healing in high-fat diet/Streptozotocin-induced diabetic rats [Pubmed:35430394] |
| Antioxidants | Bio-Evaluation of the Wound Healing Activity of Artemisia judaica L. as Part of the Plant's Use in Traditional Medicine; Phytochemical, Antioxidant, Anti-Inflammatory … [Pubmed:35204215] |
| Frontiers in Molecular Neuroscience | Red Nucleus Interleukin-6 Evokes Tactile Allodynia in Male Rats Through Modulating Spinal Pro-inflammatory and Anti-inflammatory Cytokines [Pubmed:35465093] |
| Vaccines | Age-Dependent Dynamics of Maternally Derived Antibodies (MDAs) and Understanding MDA-Mediated Immune Tolerance in Foot-and-Mouth Disease-Vaccinated … [Pubmed:35632433] |
| Biomaterials Advances | Human adipose-derived stem cell-loaded small intestinal submucosa as a bioactive wound dressing for the treatment of diabetic wounds in rats [] |
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