脑源性神经营养因子(BDNF)重组蛋白
Recombinant Brain Derived Neurotrophic Factor (BDNF)
Neurotrophin; Abrineurin
- 编号RPA011Ca01
- 物种Canis familiaris; Canine (Dog,犬) 相同的名称,不同的物种。
- 来源原核表达
- 宿主E.coli
- 内毒素水平<1.0EU/µg(LAL法测定)
- 亚细胞定位分泌
- 预测分子量14.4kDa
- 实际分子量17kDa(差异分析请参阅说明书)
- 片段与标签Arg128~Ile243 with N-terminal His Tag
- 缓冲液成份100mM NaHCO3, 500mM NaCl缓冲液(pH8.3,含有1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose和Proclin300)
- 性状冻干粉
- 纯度> 90%
- 等电点9.3
-
应用
Positive Control; Immunogen; SDS-PAGE; WB.
如果需要有生物活性的蛋白,请参见活性蛋白。 - 下载 英文说明书 中文说明书
- 规格 10µg50µg 200µg 1mg 5mg
- 价格 ¥ 1248 ¥ 3120 ¥ 6240 ¥ 18720 ¥ 46800
- 欲了解实际交易价格和更多情况,请与当地经销商联系!
序列
用法
Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
储存
避免反复冻融。2-8°C不超过一个月,-80°C不超过12个月。
稳定性
热稳定性以损失率显示。损失率是由加速降解试验决定,具体方法如下:在37°C孵育48小时,没有显著的降解或者沉淀产生。保质期内,在适当的条件下存储,损失率低于5%。
增值服务
相关产品
编号 | 适用物种:Canis familiaris; Canine (Dog,犬) | 应用(仅供研究使用,不用于临床诊断!) |
RPA011Ca01 | 脑源性神经营养因子(BDNF)重组蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
PAA011Ca01 | 脑源性神经营养因子(BDNF)多克隆抗体 | WB; IHC; ICC; IP. |
MAA011Ca21 | 脑源性神经营养因子(BDNF)单克隆抗体 | WB; IHC; ICC; IP. |
SEA011Ca | 脑源性神经营养因子(BDNF)检测试剂盒(酶联免疫吸附试验法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
LMA011Ca | 脑源性神经营养因子(BDNF)等多因子检测试剂盒(流式荧光发光法) | FLIA Kit for Antigen Detection. |
参考文献
杂志 | 参考文献 |
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Journal of the Neurological Sciences | Neuroprotective effects of adipose-derived stem cells against ischemic neuronal damage in the rabbit spinal cord [ScienceDirect: S0022510X12001219] |
International Conference on Bioscience | Effect of Benthosemapterotum Peptide on Aging in Mice with Oxidative Damage [Psrcentre: 212059] |
Neuroscience Letters | Chronic stress impairs learning and hippocampal cell proliferation in senescence-accelerated prone mice [ScienceDirect: S0304394010015788] |
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Behavioural Brain Research | The effects of Ginkgo biloba extract on cognitive functions in aged female rats: The role of oxidative stress and brain-derived neurotrophic factor [Pubmed:25446810] |
Neurochemical Research | Heme Oxygenase-1 Protects Neurons from Ischemic Damage by UpreCavia (Guinea pig )lating Expression of Cu,Zn-SuperoxideDismutase, Catalase, and Brain-Derived Neurotrophic Factor in the Rabbit Spinal Cord. [Pubmed:26559686] |
Exp Ther Med. | Effects of docosahexaenoic acid on learning and memory impairment induced by repeated propofol anesthesia in young rats [pmc:PMC4812310] |
Genet Mol Res | Changes in growth factor levels in the cerebrospinal fluid of autism patients after transplantation of human umbilical cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells [Pubmed:27323064] |
The International Journal af Applied Research in Veterinary Medicine | Effect of Sample Time in Clot Tube, Temperature, and Hemolysis Status on Canine Serum Brain-Derived Neurotrophic Factor (BDNF) Concentrations: Preliminary study [articles:Vol14Iss3] |
J Chem Neuroanat. | Both secreted and the cellular levels of BDNF attenuated due to tau hyperphosphorylation in primary cultures of cortical neurons. [pubmed:27914953] |
Int Immunopharmacol. | PPARr activation ameliorates postoperative cognitive decline probably through suppressing hippocampal neuroinflammation in aged mice. [pubmed:27940378] |
The Journal of Maternal-Fetal & Neonatal Medicine | Differential expression of cord blood neurotrophins in gestational diabetes: the impact of fetal growth abnormalities [pubmed:28081639] |
IOS Press Content Library | An Intranasal Formulation of Erythropoietin (Neuro-EPO) Prevents Memory Deficits and Amyloid Toxicity in the APPSwe Transgenic Mouse Model of Alzheimer's … [articles:journal-of-alzheimers-disease] |
Bipolar Disorders | Long‐term lithium treatment increases intracellular and extracellular brain‐derived neurotrophic factor (BDNF) in cortical and hippocampal neurons at subtherapeutic … [bdi.12449] |
Elsevier | Associations of blood parameters with age, feed efficiency and sampling routine in young beef bulls [science:article] |
journal of allergy and clinical immunology | Water-soluble chitosan inhibits nerve growth factor and attenuates allergic inflammation in mite allergen–induced allergic rhinitis [pubmed:28412394] |
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Pharmacological Research | N-3 PUFA diet enrichment prevents amyloid beta-induced depressive-like phenotype [Pubmed:29203442] |
Experimental Neurology | Preterm umbilical cord blood derived mesenchymal stem/stromal cells protect preterm white matter brain development against hypoxia-ischemia [Pubmed:30012511] |
Nutrients | Early Life Vitamin C Deficiency Does Not Alter Morphology of Hippocampal CA1 Pyramidal Neurons or Markers of Synaptic Plasticity in a Guinea Pig Model. [Pubmed:29890692] |
Neurotoxicity Research | Delta-9-Tetrahydrocannabinol (∆-THC) Induce Neurogenesis and Improve Cognitive Performances of Male Sprague Dawley Rats [Pubmed:28933048] |
Neurotoxicology | Amelioration by nitric oxide (NO) mimetics on neurobehavioral and biochemical changes in experimental model of Alzheimer's disease in rats [Pubmed:29522778] |
Neuroscience Letters | Long term Westernized diet leads to region-specific changes in brain signaling mechanisms [Pubmed:29655945] |
Applied Physiology Nutrition and Metabolism | Changes in exercise capacity and serum BDNF following long-term sprint interval training in well-trained cyclists [Pubmed: 30286300] |
Heliyon | Establishment and evaluation of a novel mouse model of peri/postmenopausal depression [Doi: 10.1016/j.heliyon.2019.e01195] |
BioMed Research International | Administration of Repetitive Transcranial Magnetic Stimulation Attenuates Aβ1-42-Induced Alzheimer's Disease in Mice by Activating β-Catenin Signaling [] |
International Journal of Immunopathology and Pharmacology | Effect of voluntary running on expression of myokines in brains of rats with depression [Pubmed: 30834799] |
American Journal of Emergency Medicine | Clinical usefulness of brain-derived neurotrophic factor and visinin-like protein-1 in early diagnostic tests for acute stroke [Pubmed: 30826210] |
Neurochemistry International | Monoaminergic system is implicated in the antidepressant-like effect of hyperoside and protocatechuic acid isolated from Impatiens glandulifera Royle in mice [Pubmed: 31077758] |
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA | Physical Exercise Increased Brain-Derived Neurotrophic Factor in Elderly Population with Depression [Pubmed: 30994834] |
Journal of Alzheimer's Disease | Regular Exercise Enhances Cognitive Function and Intracephalic GLUT Expression in Alzheimer's Disease Model Mice [Pubmed: 31561359] |
Biological Trace Element Research | Cognitive Decline of Rats with Chronic Fluorosis Is Associated with Alterations in Hippocampal Calpain Signaling [Pubmed: 31797207] |
Psychopharmacology | Chronic harmine treatment has a delayed effect on mobility in control and socially defeated rats [Pubmed: 32088835] |
Experimental and Therapeutic Medicine | Involvement of neurotrophic signaling in doxorubicin‑induced cardiotoxicity [Pubmed: 32010279] |
Journal of Critical Care | Association of neuronal repair biomarkers with delirium among survivors of critical illness [Pubmed: 31896448] |
Journal of Clinical Neuroscience | CSF levels of a set of neurotrophic factors (brain-derived neurotrophic factor, nerve growth factor) and neuropeptides (neuropeptide Y, galanin) in epileptic children [Pubmed: 32327377] |
MOLECULAR NUTRITION & FOOD RESEARCH | Hyperlipidemia Down‐Regulate Brain Antioxidant Defense Enzymes and Neurotrophins in Rats: Assessment of the Modulatory Potential of EPA+ DHA and … [Pubmed: 32918393] |
Neuropharmacology | Impaired LTD-like motor cortical plasticity in female patients with major depression disorder [Pubmed: 32791084] |
COLLOIDS AND SURFACES B-BIOINTERFACES | Effects of gold nanoparticles administration through behavioral and oxidative parameters in animal model of parkinson's disease [Pubmed: 32777662] |
Neurotoxicology | Involvement of hippocampal agmatine in β1-42 amyloid induced memory impairment, neuroinflammation and BDNF signaling disruption in mice [Pubmed: 32522471] |
Journal of Veterinary Behavior | Comparison of serum brain-derived neurotrophic factor (BDNF) in dogs with and without separation anxiety [] |
Food & Function | Nicotinamide riboside alleviates alcohol-induced depression-like behaviours in C57BL/6J mice by altering the intestinal microbiota associated with microglial … [] |
Short-but no long-term effect of social stress in rodent depressive-like behavior is not affected by chronic treatment with Harmine [] | |
bioinformatics and biomedical engineering | Blood Plasma Trophic Growth Factors Predict the Outcome in Patients with Acute Ischemic Stroke [] |
Overektomize dişi sıçanlarda beyin oksidatif stres, bdnf ve inflamatuar cevap düzeyleri ile nörodavranışsal değişiklikler üzerine anjiyotensin II İnhibisyonunun etkisi [] | |
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY | Increased serum brain-derived neurotrophic factor and adrenocorticotropic hormone levels are associated with obsessive compulsive disorder in medication?free?¡ [33389158] |
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | Sea urchin gangliosides exhibit neuritogenic effects in neuronal PC12 cells via TrkA- and TrkB-related pathways [33589896] |
Neuropsychiatr Dis Treat | Repetitive Transcranial Magnetic Stimulation Improves Mild Cognitive Impairment Associated with Alzheimer's Disease in Mice by Modulating the miR-567 … [34239303] |
Einstein (Sao Paulo) | Tropomyosin receptor kinase B-mediated signaling in integration of neuropathic pain and obesity in diabetic polyneuropathy [34586159] |
Metab Brain Dis | Moderate-intensity continuous training and high-intensity interval training improve cognition, and BDNF levels of middle-aged overweight men [34762211] |
Transl Psychiatry | Lithium augmentation of ketamine increases insulin signaling and antidepressant-like active stress coping in a rodent model of treatment-resistant depression [34824208] |
Iranian Journal of Basic Medical Sciences | Adrenomedullin increases cAMP accumulation and BDNF expression in rat DRG and spinal motor neurons [34712429] |
J Sex Med | Endogenous Deficiency of Brain-Derived Neurotrophic Factor Induces the Downregulation of Tryptophan Hydroxylase-2 Expression in Raphe Nuclei of Rapid … [34384732] |
Cell Biochem Funct | CNTs‐CaP/chitosan‐coated AZ91D magnesium alloy extract promoted rat dorsal root ganglia neuron growth via activating ERK signalling pathway [34296452] |
J Endocrinol Invest | Serum alpha-melanocyte-stimulating hormone (a-MSH), brain-derived neurotrophic factor (BDNF), and agouti-related protein (AGRP) levels in children with Prader … [Pubmed:35098494] |
Clinical Rheumatology | Gender influence on clinical manifestations, depressive symptoms and brain-derived neurotrophic factor (BDNF) serum levels in patients affected by … [Pubmed:35344113] |
Sci Rep | Associations between serum levels of brain-derived neurotrophic factor, corticotropin releasing hormone and mental distress in vitiligo patients [Pubmed:35508633] |
Pharmaceutics | Co-Delivery of Docosahexaenoic Acid and Brain-Derived Neurotropic Factor from Electrospun Aligned Core–Shell Fibrous Membranes in Treatment of Spinal Cord … [Pubmed:35214053] |
Molecular Biology Reports | Umbilical cord-derived mesenchymal stem cell conditioned medium reverses neuronal oxidative injury by inhibition of TRPM2 activation and the JNK signaling … [Pubmed:35585377] |
Journal of Complementary Medicine Research | Effect of herbal formulation Sharbat Ahmad Shahi on serum BDNF level in mild to moderate cases of depressive disorder [] |
AFRICAN JOURNAL OF BIOCHEMISTRY RESEARCH | Medicinal effects of Saffron on obese animals by reducing Castellis risk index to protect from cardio-pathology and psychological distress [] |
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