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可罗索(KL)重组蛋白

Recombinant Klotho (KL)

KLa; Klotho Alpha

  • 可罗索(KL)重组蛋白 产品包装(模拟)
  • 可罗索(KL)重组蛋白 产品包装(模拟)
  • 可罗索(KL)重组蛋白 Figure . Gene Sequencing (extract)
  • RPH757Ra01.jpg Figure. SDS-PAGE
  • Certificate 通过ISO 9001、ISO 13485质量体系认证

序列

用法

Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

储存

避免反复冻融。2-8°C不超过一个月，-80°C不超过12个月。

稳定性

热稳定性以损失率显示。损失率是由加速降解试验决定，具体方法如下：在37°C孵育48小时，没有显著的降解或者沉淀产生。保质期内，在适当的条件下存储，损失率低于5%。

相关产品

编号 适用物种：Rattus norvegicus (Rat，大鼠) 应用(仅供研究使用，不用于临床诊断！)
APH757Ra01 可罗索(KL)活性蛋白 Cell culture; Activity Assays.
RPH757Ra02 可罗索(KL)重组蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
RPH757Ra01 可罗索(KL)重组蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
PAH757Ra02 可罗索(KL)多克隆抗体 WB; IHC; ICC; IP.
PAH757Ra01 可罗索(KL)多克隆抗体 WB; IHC; ICC; IP.
MAH757Ra21 可罗索(KL)单克隆抗体 WB; IHC; ICC; IP.
SEH757Ra 可罗索(KL)检测试剂盒(酶联免疫吸附试验法) Enzyme-linked immunosorbent assay for Antigen Detection.
LMH757Ra 可罗索(KL)等多因子检测试剂盒(流式荧光发光法) FLIA Kit for Antigen Detection.

参考文献

杂志 参考文献
Life Sciences High phosphate feeding induced arterial medial calcification in uremic rats: Roles of Lanthanum carbonate on protecting vasculature [Pubmed: 24012609]
EXPERIMENTAL & CLINICAL CARDIOLOGY Sick Sinus Syndrome May Attribute to the Decrease of ?±-klotho Protein in Mice [Com:Source]
Int J Clin Exp Pathol.? α-Klotho is an acute phase protein and altered by restraint stress in mice [Pubmed:Pmc4203207]
Annales de Biologie Clinique Les biomarqueurs des calcifications vasculaires [PubMed: 26069069]
Mol Med Rep Effect of secondary hyperparathyroidism serum on endothelial cells and intervention with Klotho [PubMed: 25873020]
Calcif Tissue Int Human Preosteoblastic Cell Culture from a Patient with Severe Tumoral Calcinosis-Hyperphosphatemia Due to a NewGALNT3 [PubMed: 25899975]
中华内分泌代谢杂志 抗衰老蛋白Klotho 阻断高糖培养的大鼠肾小球系膜细胞TLR4/NF-κB p65/NGAL 通路的激活及其作用机制 [Cn: Article]
Mol Cell Endocrinol The function of miR-199a-5p/Klotho regulating TLR4/NF-κB p65/NGAL pathways in rat mesangial cells cultured with high glucose and the mechanism [PubMed: 26419931]
Arch Med Sci Soluble Klotho protein as a novel serum biomarker in patients with acromegaly [pmc:PMC4754356]
Am J Nephrol Klotho Deficiency Aggravates Tacrolimus-Induced Renal Injury via the Phosphatidylinositol 3-Kinase-Akt-Forkhead Box Protein O Pathway [Pubmed:27174564]
Sci Rep. Klotho preservation via histone deacetylase inhibition attenuates chronic kidney disease-associated bone injury in mice. [pubmed:28387374]
Nephrology Is there a role for newer biomarkers in chronic kidney disease-mineral and bone disorder management? [pubmed:28429560]
Journal of Integrative Nephrology & Andrology Associations between serum fibroblast growth factor 23 level and intradialytic hypotension in hemodialysis patients [issn:2394-2916]
International Journal of Clinical and Experimental Pathology Protective effect of restructuring klotho protein combined with trimetazidine on myocardial injury in mice [ISSN:1936-2625]
Journal of veterinary medical science Changes of Klotho protein and Klotho mRNA expression in a hydroxy-L-proline induced hyperoxaluric rat model [pubmed:28943597]
Cellular Physiology and Biochemistry Klotho Reduces Necroptosis by Targeting Oxidative Stress Involved in Renal Ischemic-Reperfusion Injury [Pubmed:29550818]
American Journal of Translational Research Advanced maternal age impairs spatial learning capacity in young adult mouse offspring [Pubmed:29636887]
Journal of Diabetes and its Complications Clinical implication of alterations in serum Klotho levels in patients with type 2 diabetes mellitus and its associated complications [Pubmed:30042059]
Medical Science Monitor Klotho Inhibits Proliferation and Migration of Angiotensin II-Induced Vascular Smooth Muscle Cells (VSMCs) by Modulating NF-κB p65, Akt, and Extracellular Signal … [Pubmed:30004089]
Nephrology Dialysis Transplantation High-serum phosphate and parathyroid hormone distinctly regulate bone loss and vascular calcification in experimental chronic kidney disease [Pubmed: 30189026]
BMC Nephrology The role of klotho in chronic kidney disease [Pubmed: 30348110]
Nature Communications Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration [Pubmed: 30451844]
Kidney International Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome [Pubmed: 30770217]
Expert Opinion on Therapeutic Targets The use of LP533401 as a therapeutic option for renal osteodystrophy affects, renal calcium handling, vitamin D metabolism and bone health in uremic rats [Pubmed: 30801205]
Mol Immunol CD317 mediates immunocytolysis resistance by RICH2/cytoskeleton-dependent membrane protection [Pubmed: 33223223]
Journal of Clinical Hypertension Effects of salt intervention on serum levels of Klotho influenced by salt sensitivity [Pubmed: 33164306]
CURRENT EYE RESEARCH Expression of α-Klotho is downregulated and associated with oxidative stress in the lens in streptozotocin-induced diabetic rats [Pubmed: 32744464]
international immunopharmacology Klotho ameliorates the onset and progression of cataract via suppressing oxidative stress and inflammation in the lens in streptozotocin-induced diabetic rats [Pubmed: 32438076]
Purinergic Signalling P2X7 siRNA targeted to the kidneys increases klotho and delays the progression of experimental diabetic nephropathy. [Pubmed: 32377919]
Oxidative Medicine and Cellular Longevity Ameliorating Effect of Klotho Protein on Rat Heart during I/R Injury [Pubmed: 33123314]
NEUROSCIENCE Increased Plasma Level of Longevity Protein Klotho as a Potential Indicator of Cognitive Function Preservation in Patients With Schizophrenia [Pubmed: 32612508]
Pharmacological Reports ¦ÁKlotho protein has therapeutic activity in contrast-induced acute kidney injury by limiting NLRP3 inflammasome-mediated pyroptosis and promoting autophagy [33675964]
J Mol Neurosci Investigation of the Role of Induced Overexpression of the Isolated Secreted Klotho on the A-172 Human Glioblastoma Cells [Pubmed:35112226]
Reproductive Biology and Endocrinology Expression of Klotho in Follicles of Patients With Polycystic Ovary Syndrome and Its Clinical Significance []
Journal of Ovarian Research Klotho is a prognostic indicator of oocytes qualities in polycystic ovary syndrome []
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