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铁调素(Hepc)多克隆抗体

Polyclonal Antibody to Hepcidin (Hepc)

HAMP; HFE2B; PLTR; LEAP1; Hepcidin Antimicrobial Peptide; Liver-expressed antimicrobial peptide 1; Putative liver tumor regressor

  • 铁调素(Hepc)多克隆抗体 产品包装(模拟)
  • 铁调素(Hepc)多克隆抗体 产品包装(模拟)
  • PAB979Po01.jpg Figure. Western Blot; Sample: Recombinant Hepcidin, Porcine.
  • 铁调素(Hepc)多克隆抗体 Western Blot; Sample: Human Urine
    Primary Ab: 0.4µg/ml Rabbit Anti-Porcine Hepc Antibody
    Second Ab: 0.2μg/ml HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
    (Catalog: SAA544Rb19)
  • Certificate 通过ISO 9001、ISO 13485质量体系认证

特异性

该抗体是针对Hepc的兔多克隆抗体。在免疫组织化学染色和免疫印迹实验中能识别Hepc。

用法

Western blotting: 0.5-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

储存

经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。

稳定性

热稳定性以损失率显示。损失率是由加速降解试验决定，具体方法如下：在37°C孵育48小时，没有显著的降解或者沉淀产生。保质期内，在适当的条件下存储，损失率低于5%。

赠品

相关产品

编号 适用物种：Sus scrofa; Porcine (Pig，猪) 应用(仅供研究使用，不用于临床诊断！)
RPB979Po01 铁调素(Hepc)重组蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
PAB979Po01 铁调素(Hepc)多克隆抗体 WB; IHC; ICC; IP.
MAB979Po21 铁调素(Hepc)单克隆抗体 WB; IHC; ICC; IP.
CEB979Po 铁调素(Hepc)检测试剂盒(酶联免疫吸附试验法) Enzyme-linked immunosorbent assay for Antigen Detection.
LMB979Po 铁调素(Hepc)等多因子检测试剂盒(流式荧光发光法) FLIA Kit for Antigen Detection.

参考文献

杂志 参考文献
World J Gastroenterol. Hepcidin expression in colon during trinitrobenzene sulfonic acid-induced colitis in rats [Pubmed: 24764672]
International Journal of Advanced Research Modulations of serum hepcidin, IL6 and iron status by different exercise regimens in ovarectomized rats [Com:Source]
Neurochemical Journal Serum iron metabolism markers including hepcidin in multiple sclerosis patients [Springer:Source]
Afro-Egypt J Infect Endem Dis Monitoring Hepcidin Level in Chronic Hepatitis C Virus Patients during Therapy [Zu:Source]
Gastroenterology Gluconeogenic signals regulate iron homeostasis via hepcidin in mice [Pubmed:Pmc3989026]
J Card Fail. Inappropriate expression of hepcidin by liver congestion contributes to anemia and relative iron deficiency [Pubmed:24440572]
Food Funct. The action of JAK, SMAD and ERK signal pathways on hepcidin suppression by polysaccharides from Angelica sinensis in rats with iron deficiency anemia [Pubmed:24752529]
Free Radic Res. Changes in skeletal muscle iron metabolism outpace amyotrophic lateral sclerosis onset in transgenic rats bearing the G93A hmSOD1 gene mutation [Pubmed:25175826]
Saudi J Kidney Dis Transpl. Hepcidin and regulation of iron homeostasis in maintenance hemodialysis patients [Pubmed:25193892]
J Endocrinol Invest.? The interplay among iron metabolism, endothelium and inflammatory cascade in dysmetabolic disorders [Pubmed:25245337]
Gastroenterology Research and Practice An Evaluation of the Correlation between Hepcidin Serum Levels and Disease Activity in Inflammatory Bowel Disease [Pubmed:25628652]
Clin Lab. Serum hepcidin levels in Bulgarian population. [Pubmed:25651734]
The Tohoku Journal of Experimental Medicine Liver Congestion in Heart Failure Contributes to Inappropriately Increased Serum Hepcidin despite Anemia [Pubmed:25742771]
Cancer Res Hepcidin regulation in prostate and its disruption in prostate cancer [PubMed: 25858146]
Biochem Biophys Res Commun B-cell translocation gene 2 promotes hepatic hepcidin production via induction of Yin Yang 1 [PubMed: 25839654]
Blood Purif Effect of a More Permeable Dialysis Membrane on ESA Resistance in Hemodialysis Patients - A Pilot Investigation [PubMed: 26536083]
Asian Journal of Clinical Nutrition Urinary Hepcidin in Diagnosis of Iron Deficiency Anemia [Openview: E01Ad7C4A9109Ed5Fadb03Ec206D7Bdc]
Front Psychol Ferrous sulfate, but not iron polymaltose complex, aggravates local and systemic inflammation and oxidative stress in dextran sodium sulfate-induced colitis in rats [PubMed: 25852597]
Biol Trace Elem Res Iron Supplementation Attenuates the Inflammatory Status of Anemic Piglets by Regulating Hepcidin [PubMed: 25774043]
APS Journals Kupffer cell depletion protects against the steatosis, but not the liver damage, induced by marginal copper, high fructose diet in male rats. [PubMed: 25813056]
European Journal of Haematology Hepcidin in tumor‐related iron deficiency anemia and tumor‐related anemia of chronic disease: pathogenic mechanisms and diagnosis [PubMed: 24954786]
WJA The Effects of Treatment on Serum Hepcidin and Iron Homeostasis in HIV-1-Infected In-dividuals [Journal: 59107]
Nutrition, Metabolism and Cardiovascular Diseases Hepcidin and iron metabolism associated with cardiometabolic risk factors in children: A case-control study. [Pubmed:27139516]
Food Funct The effects of polysaccharides from the root of Angelica sinensis on tumor growth and iron metabolism in H22-bearing mice [Pubmed:26757699]
Antioxid Redox Signal. Hydrogen sulfide attenuates inflammatory hepcidin by reducing IL-6 secretion and promoting SIRT1-mediated STAT3 deacetylation [Pubmed:26154696]
BioMed Research International The Impact of Acute Matriptase Inhibition in Hepatic Inflammatory Models. [pubmed:27642598]
Frontiers in Neuroscience In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution. [pubmed:27729845]
Experimental Biology and Medicine Effects of iron supplementation in mice with hypoferremia induced by obesity [pubmed:27439539]
Nutrition, Metabolism and Cardiovascular Diseases Hepcidin and iron metabolism associated with cardiometabolic risk factors in children: A case–control study [pubmed:27139516]
PLOS ONE S-Propargyl-Cysteine, a Novel Hydrogen Sulfide Donor, Inhibits Inflammatory Hepcidin and Relieves Anemia of Inflammation by Inhibiting IL-6/STAT3 Pathway. [pubmed:27649298]
Endocrine connections Hepcidin links gluco-toxicity to pancreatic beta cell dysfunction by inhibiting Pdx-1 expression [pubmed:28179377]
Maternal and cord blood hepcidin levels based on gestational weeks in term and preterm infants [publication:305921433_Maternal_and_cord_blood_hepc]
Oxidative Medicine and Cellular Longevity Acidic Polysaccharide from Angelica sinensis Reverses Anemia of Chronic Disease Involving the Suppression of Inflammatory Hepcidin and NF-κB Activation [pubmed:29147463]
The Royal Society of Chemistry Silkworm feces extract improves iron deficiency anemia via suppressing hepcidin expression and promoting iron-regulatory proteins expression [DOI: 10.1039/C7RA09576G]
Journal of Inflammation Evaluation of a competitive hepcidin ELISA assay in the differential diagnosis of iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients [10.1186:s12950-017-0166-3]
Antioxidants and Redox Signaling AMPK serves as a Therapeutic Target against Anemia of Inflammation [pubmed:27923278]
NutriciónHospitalaria Micronutrient supplementation in gastric bypass surgery: prospective study on infl ammation and iron metabolism in premenopausal women [10.20960/nh.1162]
The Japanese Society of Hematology Hepcidin suppression in β‑thalassemia is associated with the down‑regulation of atonal homolog 8 [pubmed:28405918]
Tuberculosis Modulation of iron status biomarkers in tuberculosis-diabetes co-morbidity [10.1016/j.tube.2017.11.011]
Oman Medical Journal The Role of Insulin Therapy in Correcting Hepcidin Levels in Patients with Type 2 Diabetes Mellitus. [pubmed:28584599]
Cellular Physiology and Biochemistry The Effects of Angelica Sinensis Polysaccharide on Tumor Growth and Iron Metabolism by Regulating Hepcidin in Tumor-Bearing Mice [Pubmed:29843136]
Cellular Microbiology  inhibits ferroportin translation by modulating FBXL5‐IRP2 axis for its growth within host macrophages [Pubmed:29470856]
Journal of Histochemistry & Cytochemistry Acute and Chronic Iron Overloading Differentially Modulates the Expression of Cellular Iron-homeostatic Molecules in Normal Rat Kidney [Pubmed:29873589]
Clinical and Experimental Medicine Increased NGAL level associated with iron store in chronic kidney disease with anemia [Pubmed:29909502]
Hematology Relationship between obesity and iron deficiency anemia: is there a role of hepcidin? [Pubmed:29318945]
Hepcidin serum levels in HCV chronically mono-infected naïve patients, compared to healthy individuals [77856]
Food & Function Effect of iron supplement from microalgae on the treatment of iron-deficient anemia in rats [Doi: 10.1039/C8FO01696H]
Haematologica New thiazolidinones reduce iron overload in mouse models of hereditary hemochromatosis and β-thalassemia [Pubmed: 30792208]
Ann Intensive Care Inflammatory anemia-associated parameters are related to 28-day mortality in patients with sepsis admitted to the ICU: a preliminary observational study [Pubmed: 31183575]
Journal of Functional Foods Dietary gelatin enhances non-heme iron absorption possibly via regulation of systemic iron homeostasis in rats []
Naunyn Schmiedebergs Arch Pharmacol. 3-Amidinophenylalanine-derived matriptase inhibitors can modulate hepcidin production in vitro [Pubmed: 31659405]
DEVELOPMENT GROWTH & DIFFERENTIATION H2O2 induces oxidative stress damage through the BMP‐6/SMAD/hepcidin axis [Pubmed: 32012242]
Frontiers in Physiology Increased Hepcidin Levels During a Period of High Training Load Do Not Alter Iron Status in Male Elite Junior Rowers [Pubmed: 32038278]
J Korean Med Sci Can Calprotectin Show Subclinical Inflammation in Familial Mediterranean Fever Patients? [Pubmed: 32174062]
nephrology dialysis transplantation Iron kinetics following treatment with sucroferric oxyhydroxide or ferric citrate in healthy rats and models of anaemia, iron overload or inflammation [Pubmed: 32259248]
mikrochimica acta Gold-silver core-shell nanoparticle–based impedimetric immunosensor for detection of iron homeostasis biomarker hepcidin [Pubmed: 33095336]
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY Circulating Osteocyte‐Related Biomarkers (vitamin D, sclerostin, dickkopf-1), hepcidin, and oxidative stress markers in early breast cancer: their impact in … [Pubmed: 33065276]
Sleep Breath Relation of serum hepcidin levels and restless legs syndrome in chronic hemodialysis patients [Pubmed: 33029690]
journal of trace elements in experimental medicine Difference in iron metabolism may partly explain sex-related variability in the manifestation of Wilson's disease [Pubmed: 32937238]
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Neurobiology of Aging Estrogen deficiency is associated with brain iron deposition via upregulation of hepcidin expression in aged female mice [Pubmed: 32920472]
The Egyptian Journal of Haematology Urinary hepcidin concentration in assessment of iron homeostasis in pediatrics []
COMPARATIVE MONITORING OF THE ENZYME ACTIVITY OF BONE METABOLISM IN PATIENTS AFTER DENTAL IMPLANTATION []
Serum iron, prealbumin, D-dimer and prothrombin time are indicators of the diagnosis, severity and outcome of Salmonella enterica serovar Enteritidis infection []
Гепсидин и индекс фиброза печени MELD-XI как маркеры полиорганной недостаточности у пациентов хронической сердечной недостаточностью с … []
Ассоциации уровней NT-proBNP и гепсидина с клинико-лабораторными параметрами у больных хронической сердечной недостаточностью с разной … []
Biosci Rep Correlation of hepcidin and serum ferritin levels in thalassemia patients at Chiang Mai University Hospital [33565577]
Biometals Iron metabolism is disturbed and anti-copper treatment improves but does not normalize iron metabolism in Wilson's disease [33555495]
J Mol Cell Cardiol Systemic iron deficiency does not affect the cardiac iron content and progression of heart failure [34139233]
Continuous Veno-Venous Hemofiltration (CVVH) Improves Iron Metabolism Disorders in Patients With Sepsis: A Single-Center Prospective Cohort Study []
Reports of Biochemistry & Molecular Biology Evaluation of Serum Cyclooxygenase, Hepcidin Levels in Acute Renal Injury (AKI) Patients Following Cardiac Catheterization []
Food Funct High-dose ferric citrate supplementation attenuates omega-3 polyunsaturated fatty acid biosynthesis via downregulating delta 5 and 6 desaturases in rats with high-fat … [34787162]
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PeerJ Resveratrol ameliorates iron overload induced liver fibrosis in mice by regulating iron homeostasis [Pubmed:35698613]
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Food Bioscience Roles of homopolymeric apoferritin in alleviating alcohol-induced liver injury []
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