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可罗索(KL)多克隆抗体

Polyclonal Antibody to Klotho (KL)

KLa; Klotho Alpha

  • 可罗索(KL)多克隆抗体 产品包装(模拟)
  • 可罗索(KL)多克隆抗体 产品包装(模拟)
  • PAH757Hu01.jpg Figure. Western Blot; Sample: Recombinant KL, Human.
  • Certificate 通过ISO 9001、ISO 13485质量体系认证

特异性

该抗体是针对KL的兔多克隆抗体。在免疫组织化学染色和免疫印迹实验中能识别KL。

用法

Western blotting: 0.01-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

储存

经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。

稳定性

热稳定性以损失率显示。损失率是由加速降解试验决定，具体方法如下：在37°C孵育48小时，没有显著的降解或者沉淀产生。保质期内，在适当的条件下存储，损失率低于5%。

赠品

相关产品

编号 适用物种：Homo sapiens (Human，人) 应用(仅供研究使用，不用于临床诊断！)
RPH757Hu01 可罗索(KL)重组蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
PAH757Hu01 可罗索(KL)多克隆抗体 WB; IHC; ICC; IP.
MAH757Hu21 可罗索(KL)单克隆抗体 WB
SEH757Hu 可罗索(KL)检测试剂盒(酶联免疫吸附试验法) Enzyme-linked immunosorbent assay for Antigen Detection.
HEH757Hu 可罗索(KL)检测试剂盒(酶联免疫吸附试验法,高敏型) Enzyme-linked immunosorbent assay for Antigen Detection.
SCH757Hu 可罗索(KL)检测试剂盒(化学发光免疫分析法) Chemiluminescent immunoassay for Antigen Detection.
LMH757Hu 可罗索(KL)等多因子检测试剂盒(流式荧光发光法) FLIA Kit for Antigen Detection.
KSH757Hu01 可罗索(KL)检测试剂盒DIY材料(酶联免疫吸附试验法) Main materials for "Do It (ELISA Kit) Yourself".

参考文献

杂志 参考文献
Life Sciences High phosphate feeding induced arterial medial calcification in uremic rats: Roles of Lanthanum carbonate on protecting vasculature [Pubmed: 24012609]
EXPERIMENTAL & CLINICAL CARDIOLOGY Sick Sinus Syndrome May Attribute to the Decrease of ?±-klotho Protein in Mice [Com:Source]
Int J Clin Exp Pathol.? α-Klotho is an acute phase protein and altered by restraint stress in mice [Pubmed:Pmc4203207]
Annales de Biologie Clinique Les biomarqueurs des calcifications vasculaires [PubMed: 26069069]
Mol Med Rep Effect of secondary hyperparathyroidism serum on endothelial cells and intervention with Klotho [PubMed: 25873020]
Calcif Tissue Int Human Preosteoblastic Cell Culture from a Patient with Severe Tumoral Calcinosis-Hyperphosphatemia Due to a NewGALNT3 [PubMed: 25899975]
中华内分泌代谢杂志 抗衰老蛋白Klotho 阻断高糖培养的大鼠肾小球系膜细胞TLR4/NF-κB p65/NGAL 通路的激活及其作用机制 [Cn: Article]
Mol Cell Endocrinol The function of miR-199a-5p/Klotho regulating TLR4/NF-κB p65/NGAL pathways in rat mesangial cells cultured with high glucose and the mechanism [PubMed: 26419931]
Arch Med Sci Soluble Klotho protein as a novel serum biomarker in patients with acromegaly [pmc:PMC4754356]
Am J Nephrol Klotho Deficiency Aggravates Tacrolimus-Induced Renal Injury via the Phosphatidylinositol 3-Kinase-Akt-Forkhead Box Protein O Pathway [Pubmed:27174564]
Sci Rep. Klotho preservation via histone deacetylase inhibition attenuates chronic kidney disease-associated bone injury in mice. [pubmed:28387374]
Nephrology Is there a role for newer biomarkers in chronic kidney disease-mineral and bone disorder management? [pubmed:28429560]
Journal of Integrative Nephrology & Andrology Associations between serum fibroblast growth factor 23 level and intradialytic hypotension in hemodialysis patients [issn:2394-2916]
International Journal of Clinical and Experimental Pathology Protective effect of restructuring klotho protein combined with trimetazidine on myocardial injury in mice [ISSN:1936-2625]
Journal of veterinary medical science Changes of Klotho protein and Klotho mRNA expression in a hydroxy-L-proline induced hyperoxaluric rat model [pubmed:28943597]
Cellular Physiology and Biochemistry Klotho Reduces Necroptosis by Targeting Oxidative Stress Involved in Renal Ischemic-Reperfusion Injury [Pubmed:29550818]
American Journal of Translational Research Advanced maternal age impairs spatial learning capacity in young adult mouse offspring [Pubmed:29636887]
Journal of Diabetes and its Complications Clinical implication of alterations in serum Klotho levels in patients with type 2 diabetes mellitus and its associated complications [Pubmed:30042059]
Medical Science Monitor Klotho Inhibits Proliferation and Migration of Angiotensin II-Induced Vascular Smooth Muscle Cells (VSMCs) by Modulating NF-κB p65, Akt, and Extracellular Signal … [Pubmed:30004089]
Nephrology Dialysis Transplantation High-serum phosphate and parathyroid hormone distinctly regulate bone loss and vascular calcification in experimental chronic kidney disease [Pubmed: 30189026]
BMC Nephrology The role of klotho in chronic kidney disease [Pubmed: 30348110]
Nature Communications Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration [Pubmed: 30451844]
Kidney International Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome [Pubmed: 30770217]
Expert Opinion on Therapeutic Targets The use of LP533401 as a therapeutic option for renal osteodystrophy affects, renal calcium handling, vitamin D metabolism and bone health in uremic rats [Pubmed: 30801205]
Mol Immunol CD317 mediates immunocytolysis resistance by RICH2/cytoskeleton-dependent membrane protection [Pubmed: 33223223]
Journal of Clinical Hypertension Effects of salt intervention on serum levels of Klotho influenced by salt sensitivity [Pubmed: 33164306]
CURRENT EYE RESEARCH Expression of α-Klotho is downregulated and associated with oxidative stress in the lens in streptozotocin-induced diabetic rats [Pubmed: 32744464]
international immunopharmacology Klotho ameliorates the onset and progression of cataract via suppressing oxidative stress and inflammation in the lens in streptozotocin-induced diabetic rats [Pubmed: 32438076]
Purinergic Signalling P2X7 siRNA targeted to the kidneys increases klotho and delays the progression of experimental diabetic nephropathy. [Pubmed: 32377919]
Oxidative Medicine and Cellular Longevity Ameliorating Effect of Klotho Protein on Rat Heart during I/R Injury [Pubmed: 33123314]
NEUROSCIENCE Increased Plasma Level of Longevity Protein Klotho as a Potential Indicator of Cognitive Function Preservation in Patients With Schizophrenia [Pubmed: 32612508]
Pharmacological Reports ¦ÁKlotho protein has therapeutic activity in contrast-induced acute kidney injury by limiting NLRP3 inflammasome-mediated pyroptosis and promoting autophagy [33675964]
J Mol Neurosci Investigation of the Role of Induced Overexpression of the Isolated Secreted Klotho on the A-172 Human Glioblastoma Cells [Pubmed:35112226]
Reproductive Biology and Endocrinology Expression of Klotho in Follicles of Patients With Polycystic Ovary Syndrome and Its Clinical Significance []
Journal of Ovarian Research Klotho is a prognostic indicator of oocytes qualities in polycystic ovary syndrome []
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