淀粉样蛋白β1-42(Ab1-42)单克隆抗体
Monoclonal Antibody to Amyloid Beta Peptide 1-42 (Ab1-42)
- 编号MAA946Mi22
- 物种Homo sapiens (Human,人) 相同的名称,不同的物种。
- 来源单抗制备
- 宿主小鼠
- 效价(克隆号)C3
- Ig亚型 IgG2b Kappa
- 纯化方式蛋白A + 蛋白G亲和纯化
- 标记物无标记物
- 免疫原 -
- 缓冲液成份0.01M 磷酸盐缓冲液(pH7.4,containing 0.05% Proclin-300,50% glycerol)
- 性状液体
- 浓度1mg/ml
- 且适物种-
- 应用WB; IHC; ICC; IP.
如果抗体需用于流式细胞术,请参见流式抗体。 - 下载 英文说明书 中文说明书
- 规格 20µl100µl 200µl 1ml 10ml
- 价格 ¥ 614 ¥ 1432 ¥ 2046 ¥ 5115 ¥ 20460
- 欲了解实际交易价格和更多情况,请与当地经销商联系!
特异性
该抗体是针对Ab1-42的小鼠单克隆抗体。在免疫组织化学染色和免疫印迹实验中能识别Ab1-42。
用法
Western blotting: 0.01-3µg/mL;
Immunohistochemistry: 5-30µg/mL;
Immunocytochemistry: 5-30µg/mL;
Optimal working dilutions must be determined by end user.
储存
经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
稳定性
热稳定性以损失率显示。损失率是由加速降解试验决定,具体方法如下:在37°C孵育48小时,没有显著的降解或者沉淀产生。保质期内,在适当的条件下存储,损失率低于5%。
赠品
相关产品
编号 | 适用物种:Homo sapiens (Human,人) | 应用(仅供研究使用,不用于临床诊断!) |
MAA946Mi21 | 淀粉样蛋白β1-42(Ab1-42)单克隆抗体 | WB; IHC; ICC; IP. |
MAA946Mi22 | 淀粉样蛋白β1-42(Ab1-42)单克隆抗体 | WB; IHC; ICC; IP. |
CEA946Mi | 淀粉样蛋白β1-42(Ab1-42)检测试剂盒(酶联免疫吸附试验法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
LMA946Mi | 淀粉样蛋白β1-42(Ab1-42)等多因子检测试剂盒(流式荧光发光法) | FLIA Kit for Antigen Detection. |
参考文献
杂志 | 参考文献 |
Neuropsychopharmacology | Blockade of Tau Hyperphosphorylation and Aβ1–42 Generation by the Aminotetrahydrofuran Derivative ANAVEX2-73, a Mixed Muscarinic and σ1 Receptor Agonist, in a Nontransgenic Mouse Model of Alzheimer’s Disease [Pubmed: 23493042] |
Neuropharmacology and analgesia | The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1–42 seeding and short-term memory deficits in the Aβ25–35 mouse model of Alzheimer's disease [Pubmed: 23123349] |
世界科技研究与发展(World Sci-tech R & D) | 慢病毒介导的CBS基因过表达对原代皮质神经元 [Globesci:Source] |
南方医科大学学报 | 外源性硫化氢对高糖条件下原代神经元β淀粉样蛋白的影响 [J-Smu:Source] |
Neurochemical research | Effects of Aluminium on β-Amyloid (1–42) and Secretases (APP-Cleaving Enzymes) in Rat Brain [Pubmed:24792732] |
Indian J Biochem Biophys. | Amyloid ? lowering and cognition enhancing effects of ghrelin receptor analog [D-Lys (3)] GHRP-6 in rat model of obesity [Pubmed:25296496] |
Cell Mol Neurobiol | Anesthetic Propofol Attenuates Apoptosis, Aβ Accumulation, and Inflammation Induced by Sevoflurane Through NF-κB Pathway in Human Neuroglioma Cells [PubMed: 25809614] |
Neuropsychiatr Dis Treat | Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex [PubMed: 26316755] |
Neurochem Int | Geniposide attenuates insulin-deficiency-induced acceleration of β-amyloidosis in an APP/PS2 transgenic model of Alzheimer's disease [PubMed: 25882166] |
Journal of Alzheimer’s Parkinsonism & Dementia | The Potential Effect of Epigallocatechin-3-Gallate alone or in Combination with Vitamin E and Selenium on Alzheimer's Disease Induced by Aluminum in Rats [open-access:] |
世界科技研究与发展 | 芝麻素对高糖条件下PC12细胞Aβ和BACE-1表达的影响 [article:10299] |
Am J Alzheimers Dis Other Demen. | Tong Luo Jiu Nao, a Chinese Medicine Formula, Reduces Inflammatory Stress in a Mouse Model of Alzheimer's Disease [Pubmed:26993489] |
Світ медицини та біології | ОСОБЕННОСТИ ПРОЦЕССОВ ФОРМИРОВАНИЯ ПОКАЗАТЕЛЕЙ ФУНКЦИОНАЛЬНОГО СОСТОЯНИЯ ВЫСШЕЙ НЕРВНОЙ ДЕЯТЕЛЬНОСТИ И ХАРАКТЕРИСТИКИ ВНИМАНИЯ СТУДЕНТОВ [SMB-2016-03-062.pdf] |
世界科技研究与发展 | 芝麻素对高糖条件下PC12 细胞Aß 和BACE 1 表达的影响 [QK:92621A] |
Archives of Pharmacal Research | Geniposide attenuates the level of Aβ1–42 via enhancing leptin signaling in cellular and APP/PS1 transgenic mice [pubmed:28160136] |
Food Funct. | Effects of dietary glucocerebrosides from sea cucumber on the brain sphingolipid profiles of mouse models of Alzheimer's disease. [pubmed:28232989] |
Scientific Reports | Norovirus P particle-based active Aβ immunotherapy elicits sufficient immunogenicity and improves cognitive capacity in a mouse model of Alzheimer’s disease [articles:srep41041.ris] |
Journal of Medicinal Food | Cerebrosides from Sea Cucumber Protect Against Oxidative Stress in SAMP8 Mice and PC12 Cells [pubmed:28406733] |
Journal of Nutritional Biochemistry | Mechanisms of DHA-enriched phospholipids in improving cognitive deficits in aged SAMP8 mice with high-fat diet [Pubmed:29986309] |
Biochemical Pharmacology | Effects of n-3 PUFA enriched and n-3 PUFA deficient diets in naïve and Aβ-treated female rats [Pubmed:30028991] |
Journal of Affective Disorders | Sub-chronic celecoxib prevents soluble beta amyloid-induced depressive-like behaviour in rats [Pubmed:29879605] |
Biomedicine & Pharmacotherapy | Punicalagin ameliorates the elevation of plasma homocysteine, amyloid-β, TNF-α and apoptosis by advocating antioxidants and modulating apoptotic mediator proteins in brain modulating apoptotic mediator … [Pubmed:29579708] |
Journal of Agricultural and Food Chemistry | Effects of Astaxanthin and Docosahexaenoic-Acid-Acylated Astaxanthin on Alzheimer's Disease in APP/PS1 Double-Transgenic Mice [Pubmed:29695154] |
Neurotoxicology | Amelioration by nitric oxide (NO) mimetics on neurobehavioral and biochemical changes in experimental model of Alzheimer's disease in rats [Pubmed:29522778] |
Biochemical and Biophysical Research Communications | CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease [Pubmed:29777699] |
Oncotarget | Deletion of plasma Phospholipid Transfer Protein (PLTP) increases microglial phagocytosis and reduces cerebral amyloid-β deposition in the J20 mouse … [Pubmed:29731975] |
Experimental and Therapeutic Medicine | Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β‑amyloid production and tau hyperphosphorylation [Doi: 10.3892/etm.2018.6860] |
非编码RNA miR-137 调控tau 蛋白磷酸化和L 型钙离子通道CACNA1C 参与阿尔茨海默病的发生 [] | |
台湾农业研究 | (台灣農業研究67 (4): 355-364) 香菇柄水萃物改善糖尿病降低阿茲海默氏症罹病風險初探 [] |
The Efficacy of Sauropus androgynus Leaves Extract To Improve Cognitive Function in Wistar Rats Induced Alzheimer's [] | |
Neurotoxicity Research | Effect of Aluminum-Maltolate on the Content of Aβ Protein and the Expression of ApoER2, VLDLRs, and LRP1 in PC12-ApoE4 Cells [Pubmed: 30649678] |
Neurochemical Research | Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer's Disease and Systemic Inflammation [Pubmed: 30756214] |
Molecular and Cellular Biochemistry | Repetitive transcranial magnetic stimulation protects mice against 6-OHDA-induced Parkinson's disease symptoms by regulating brain amyloid β level [] |
PLoS One | Obstructive sleep apnea may increase the risk of Alzheimer's disease [Pubmed: 31487291] |
Metabolic Brain Disease | Nanoformulated ellagic acid ameliorates pentylenetetrazol-induced experimental epileptic seizures by modulating oxidative stress, inflammatory cytokines and … [Pubmed: 31728888] |
博士论文 | Neurobiological determinants of depressive-like symptoms in rodents [] |
Pharmacognosy Magazine | Mahanimbine-induced neuroprotection via cholinergic system and attenuated amyloidogenesis as well as neuroinflammation in lipopolysaccharides-induced … [] |
biosciences biotechnology research asia | Dietary Malted Barley Grain Improved Structure and Function of Spinal Cord of Mother Rats fed on a high cholesterol diet. [] |
Neurochem Res | Ex Vivo Investigation of Bexarotene and Nicotinamide Function as a Protect?ve Agent on Rat Synaptosomes Treated with A¦Â (1-42) [33428094] |
Food Funct | Comparative study on the effects of phosphatidylserine rich in DHA and EPA on A¦Â-intervened Alzheimer's disease using cell models [33876786] |
Int J Neurosci | Protective effects of repetitive transcranial magnetic stimulation against 6-OHDA-induced Parkinson's symptoms in a mice model: the key role of miR-409-3p/PDHB ¡ [34078216] |
Brain Res Bul | Immunization with A¦Â3-10-KLH vaccine improves cognitive function and ameliorates mitochondrial dysfunction and reduces Alzheimer's disease-like pathology in Tg ¡ [34044034] |
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | The effect of a 6-month Ketogenic Medium-Chain Triglyceride Supplement on Plasma Cardiometabolic and Inflammatory Markers in Mild Cognitive?¡ [33906081] |
Crystals | Potential Therapeutic Effects of New Ruthenium (III) Complex with Quercetin: Characterization, Structure, Gene Regulation, and Antitumor and Anti-Inflammatory Studies (RuIII/Q Novel Complex Is a Potent Immunoprotective Agent) [] |
Neurosci Lett | GPNMB mitigates Alzheimer's disease and enhances autophagy via suppressing the mTOR signal [34695452] |
Arch Gerontol Geriatr | The influence of vinpocetine alone or in combination with Epigallocatechin-3-gallate, Coenzyme COQ10, Vitamin E and Selenium as a potential neuroprotective … [34706318] |
Metab Brain Dis | Probiotics ameliorates LPS induced neuroinflammation injury on Aβ 1–42, APP, γ-β secretase and BDNF levels in maternal gut microbiota and fetal … [Pubmed:35312928] |
Medicinal Chemistry Research | New Thienopyridine Scaffold as An Antidementia Lead: In Silico Study and Biological Screening [] |
留言咨询