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高迁移率族蛋白1(HMGB1)单克隆抗体

Monoclonal Antibody to High Mobility Group Protein 1 (HMGB1)

HMG1; HMG3; SBP1; Sulfoglucuronyl Carbohydrate Binding Protein; Amphoterin; High Mobility Group Box 1 Protein

  • 高迁移率族蛋白1(HMGB1)单克隆抗体 产品包装(模拟)
  • 高迁移率族蛋白1(HMGB1)单克隆抗体 产品包装(模拟)
  • Certificate 通过ISO 9001、ISO 13485质量体系认证

特异性

该抗体是针对HMGB1的小鼠单克隆抗体。在免疫组织化学染色和免疫印迹实验中能识别HMGB1。

用法

免疫印迹：0.2-2µg/mL;1:500-5000
免疫组织化学：5-20µg/mL;1:50-200
免疫细胞化学：5-20µg/mL;1:50-200
最佳稀释倍数最终由用户决定。

储存

经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。

稳定性

热稳定性以损失率显示。损失率是由加速降解试验决定，具体方法如下：在37°C孵育48小时，没有显著的降解或者沉淀产生。保质期内，在适当的条件下存储，损失率低于5%。

赠品

相关产品

编号 适用物种：Sus scrofa; Porcine (Pig，猪) 应用(仅供研究使用，不用于临床诊断！)
RPA399Po01 高迁移率族蛋白1(HMGB1)重组蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
PAA399Po01 高迁移率族蛋白1(HMGB1)多克隆抗体 WB; IHC; ICC; IP.
MAA399Po21 高迁移率族蛋白1(HMGB1)单克隆抗体 WB; IHC; ICC; IP.
SEA399Po 高迁移率族蛋白1(HMGB1)检测试剂盒(酶联免疫吸附试验法) Enzyme-linked immunosorbent assay for Antigen Detection.
LMA399Po 高迁移率族蛋白1(HMGB1)等多因子检测试剂盒(流式荧光发光法) FLIA Kit for Antigen Detection.

参考文献

杂志 参考文献
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Viral Immunology Is HMGB1 a New Indirect Marker for Revealing Fibrosis in Chronic Hepatitis and a New Therapeutic Target in Treatment? [Wiley: source]
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Inflammation Research Mammalian target of rapamycin complex 2 regulates inflammatory response to stress [PubMed: 22899279]
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Journal of Surgical Research Plasma levels of high mobility group box 1 increase in patients with posttraumatic stress disorder after severe blunt chest trauma: a prospective cohort study [Pubmed:25016440]
Virus Research High-mobility group box-1, promising serological biomarker for the distinction of human WNV disease severity [Pubmed:25197038]
Journal of Stroke and Cerebrovascular Diseases Increased VEGF and Decreased SDF-1α in Patients with Silent Brain Infarction Are Associated with Better Prognosis after First-Ever Acute Lacunar Stroke [Pubmed:25601176]
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Oxidative Medicine and Cellular Longevity Diabetes-Induced Oxidative Stress in Endothelial Progenitor Cells May Be Sustained by a Positive Feedback Loop Involving High Mobility Group Box-1 [Journals: Omcl]
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Journal of Immunotherapy Wogonin Inhibits Tumor-derived Regulatory Molecules by Suppressing STAT3 Signaling to Promote Tumor Immunity [PubMed: 25962106]
Atherosclerosis Retinoic acid inhibits tissue factor and HMGB1 via modulation of AMPK activity in TNF-α activated endothelial cells and LPS-injected mice [PubMed: 26116962]
PLOS ONE Plasma HMGB-1 Levels in Subjects with Obesity and Type 2 Diabetes: A Cross-Sectional Study in China [PubMed: 26317615]
Int Immunopharmacol Betulin attenuates lung and liver injuries in sepsis [PubMed: 26644168]
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Int Immunopharmacol Glycyrrhizin reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and endotoxemic mice by p38/Nrf2-dependent induction of HO-1 [PubMed: 25812767]
World J Gastroenterol Overexpression of HMGB1 A-box reduced lipopolysaccharide-induced intestinal inflammation via HMGB1/TLR4 signaling in vitro [PubMed: 26167076]
Neurotoxicology Allopurinol reduces severity of delayed neurologic sequelae in experimental carbon monoxide toxicity in rats [PubMed: 25845300]
Journal of Neuroimmunology HMGB1 expression patterns during the progression of experimental autoimmune encephalomyelitis [PubMed: 25773152]
J Neuroinflammation HMGB1 release triggered by the interaction of live retinal cells and uveitogenic T cells is Fas/FasL activation-dependent [PubMed: 26394985]
PLoS One Low Shear Stress Induced HMGB1 Translocation and Release via PECAM-1/PARP-1 Pathway to Induce Inflammation Response [PubMed: 25793984]
Neuroscience Interleukin-33 is released in spinal cord and suppresses experimental autoimmune encephalomyelitis in mice [PubMed: 26363151]
Cancer Biomarkers Serum levels of HMGB1 have a diagnostic role in metastatic renal cell cancer [Pubmed:27062570]
International Immunopharmacology Oxymatrine attenuates CCl 4-induced hepatic fibrosis via modulation of TLR4-dependent inflammatory and TGF-β1 signaling pathways [Pubmed:27179304]
SpringerPlus Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by suppression ofHMGB1/RAGE/NF-ΚB pathway. [Pubmed:27026909]
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United States Patent Application METHOD OF MAKING A SKIN CARE COMPOSITION [y2016:0077080.html]
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Springerplus Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by suppression of HMGB1/RAGE/NF-ΚB pathway [pubmed:27026909]
Molecular Immunology HMGB1 blockade differentially impacts pulmonary inflammation and defense responses in poly (I: C)/LPS-exposed heart transplant mice [pubmed:27387278]
Oxidative Medicine and Cellular Longevity Reduced HMGB 1-Mediated Pathway and Oxidative Stress in Resveratrol-Treated Diabetic Mice: A Possible Mechanism of Cardioprotection of Resveratrol in … [pubmed:27833703]
BioMed Research International  High Mobility Group Box1 Protein Is Involved in Endoplasmic Reticulum Stress Induced by Clostridium difficile Toxin A [pubmed:27579314]
Cardiology The role of high mobility group box 1 protein in interleukin-18-induced myofibroblastic transition of valvular interstitial cells [pubmed:27395056]
Innate immunity HMGB1 exacerbates experimental mouse colitis by enhancing innate lymphoid cells 3 inflammatory responses via promoted IL-23 production [pubmed:27670944]
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Journal of Investigative Surgery Diagnostic Value of High-Mobility Group Box 1 (HMGB1) Protein in Acute and Perforated Appendicitis. [pubmed:27922766]
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Biomed Pharmacother. SIRT1 inhibits releases of HMGB1 and HSP70 from human umbilical vein endothelial cells caused by IL-6 and the serum from a preeclampsia patient and protects the cells from death. [pubmed:28122311]
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Scientific Reports COMMUNICATIONS Mineral particles stimulate innate immunity through neutrophil extracellular traps containing HMGB1 [pubmed:29192209]
Biochemical and Biophysical Research Communications Oxidized low-density lipoprotein promotes osteoclast differentiation from CD68 positive mononuclear cells by regulating HMGB1 release [pubmed:29146189]
Pulmonary Pharmacology & Therapeutics HMGB1 promotes HLF-1 proliferation and ECM production through activating HIF1-a-regulated aerobic glycolysis [pubmed:28571757]
Biomedical Research Correlation between high mobility group box 1 protein, tumor necrosis factor-α, and acute coronary syndrome [ISSN 0970-938X]
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BMC Complementary and Alternative Medicine Assessing the recovery from prerenal and renal acute kidney injury after treatment with single herbal medicine via activity of the biomarkers HMGB1, NGAL and KIM-1 in kidney proximal tubular cells treated by cisplatin with different doses and exposure times. [pubmed:29258482]
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Cellular physiology and biochemistry Macrophage Inflammatory Protein-2 in High Mobility Group Box 1 Secretion of Macrophage Cells Exposed to Lipopolysaccharide. [pubmed:28662496]
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Frontiers in Immunology Glycyrrhizin Protects Mice against Experimental Autoimmune Encephalomyelitis by Inhibiting HMGB1 Expression and Neuronal HMGB1 Release [Pubmed:30013568]
Oncoimmunology Bromodomain inhibition exerts its therapeutic potential in malignant pleural mesothelioma by promoting immunogenic cell death and changing the tumor immune … [Pubmed:29399399]
Cancer Immunology, Immunotherapy Tumor lysate-based vaccines: on the road to immunotherapy for gallbladder cancer [Pubmed:29600445]
Cytokine Porcine reproductive and respiratory syndrome virus induces concurrent elevation of High Mobility Group Box-1 protein and pro-inflammatory cytokines in … [Pubmed:29895396]
Frontiers in Neurology Ursolic Acid Ameliorates Inflammation in Cerebral Ischemia and Reperfusion Injury Possibly via High Mobility Group Box 1/Toll-Like Receptor 4/NFκB … [Pubmed:29867706]
Biomedicine & Pharmacotherapy Oridonin enhances the cytotoxicity of 5-FU in renal carcinoma cells by inducting necroptotic death [Pubmed:29958141]
Inflammation Research Luteolin activates ERK1/2- and Ca-dependent HO-1 induction that reduces LPS-induced HMGB1, iNOS/NO, and COX-2 expression in RAW264.7 cells and … [Pubmed:29497773]
Journal of Food and Drug Analysis Anti-inflammatory effect of cinnamaldehyde and linalool from the leaf essential oil of Cinnamomum osmophloeum Kanehira in endotoxin-induced mice [Pubmed:29389558]
Biochemical and Biophysical Research Communications Sirt1 S-nitrosylation induces acetylation of HMGB1 in LPS-activated RAW264. 7 cells and endotoxemic mice [Pubmed:29680657]
Neurological Sciences Thrombomodulin, alarmin signaling, and copeptin: cross-talk between obesity and acute ischemic stroke initiation and severity in Egyptians [Pubmed:29637447]
International Journal of Gynecology & Obstetrics Increased serum levels of high mobility group protein B1 and calprotectin in pre‐eclampsia [Pubmed:29569400]
Advances in Experimental Medicine and Biology Molecules of Damage-Associated Patterns in Bronchoalveolar Lavage Fluid and Serum in Chronic Obstructive Pulmonary Disease [Pubmed:29429028]
Taiwanese Journal of Obstetrics & Gynecology HMGB1-RAGE signaling pathway in pPROM [Pubmed:29673663]
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Journal of Pharmacological Sciences Butyrate suppresses abnormal proliferation in colonic epithelial cells under diabetic state by targeting HMGB1 [Doi: 10.1016/j.jphs.2018.07.012]
Biomaterials Science Delivery of 5'-Triphosphate RNA with Endosomolytic Nanoparticles Potently Activates RIG-I to Improve Cancer Immunotherapy [Doi: 10.1039/C8BM01064A ]
iris-AperTO []
Toxicological Sciences Apoptosis resistance in fibroblasts precedes progressive scarring in pulmonary fibrosis and is partially mediated by Toll-like receptor 4 activation [Pubmed: 31020321]
Molecular Medicine FBXW7 suppresses HMGB1-mediated innate immune signaling to attenuate hepatic inflammation and insulin resistance in a mouse model of nonalcoholic … [Pubmed: 31215394]
international immunopharmacology Dulaglutide mitigates inflammatory response in fibroblast-like synoviocytes [Pubmed: 31185450]
Food & Function Network pharmacology oriented study reveals inflammatory state-dependent dietary supplement hepatotoxicity responses in normal and diseased rats [Pubmed: 31140472]
International Immunopharmacology BET bromodomain inhibitor JQ1 promotes immunogenic cell death in tongue squamous cell carcinoma [Pubmed: 31600692]
Experimental and Therapeutic Medicine High mobility group box protein 1 neutralization therapy in ovine bacteremia: Lessons learned from an ovine septic shock model incorporating intensive care support [Pubmed: 31602200]
Oxidative Medicine and Cellular Longevity Evaluation of the Effect Derived from Silybin with Vitamin D and Vitamin E Administration on Clinical, Metabolic, Endothelial Dysfunction, Oxidative Stress Parameters … [Pubmed: 31737175]
Pathobiology Magnetic hyperthermia using self-controlled heating elements consisting of Fe-Al milling alloy induces cancer cell apoptosis while preserving skeletal muscle [Pubmed: 31722347]
Canadian Journal of Physiology and Pharmacology Suppression of high-mobility group box 1 ameliorates xerostomia in a sjogren syndrome-triggered mouse model [Pubmed: 31935120]
Neurotoxicity Research HMGB1 Mediates Paraquat-Induced Neuroinflammatory Responses via Activating RAGE Signaling Pathway [Pubmed: 31858421]
Journal of Clinical Medicine Damage-Associated Molecular Patterns and Th-Cell-Related Cytokines Released after Progressive Effort [Pubmed: 32210109]
Journal of Immunology Research Dendritic Cells Loaded with Heat Shock-Conditioned Ovarian Epithelial Carcinoma Cell Lysates Elicit T Cell-Dependent Antitumor Immune Responses In Vitro [Pubmed: 31886313]
urologic oncology A novel diagnostic tool for the detection of bladder cancer: Measurement of urinary high mobility group box-1 [Pubmed: 32312640]
International Journal of Environmental Research and Public Health Marathon Run-induced Changes in the Erythropoietin-Erythroferrone-Hepcidin Axis are Iron Dependent [Pubmed: 32316587]
VETERINARY MICROBIOLOGY Upregulation of HMGB1 Secretion in Lungs of Pigs Infected by Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus [Pubmed: 33221069]
Lab Invest Extracellular cold-inducible RNA-binding protein regulates neutrophil extracellular trap formation and tissue damage in acute pancreatitis [Pubmed: 32709888]
American Journal of Translational Research Inhibition of calpain alleviates coxsackievirus B3-induced myocarditis through suppressing the canonical NLRP3 inflammasome/caspase-1-mediated and … [Pubmed: 32509190]
STEM CELL REVIEWS AND REPORTS A Novel Evidence That Mannan Binding Lectin (MBL) Pathway of Complement Cascade Activation is Involved in Homing and Engraftment of Hematopoietic Stem … [Pubmed: 32406006]
Translational Stroke Research Glycyrrhizin Prevents Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke with Delayed Thrombolysis Through Targeting … []
stem cells international Hypoxic Wharton's Jelly Stem Cell Conditioned Medium Induces Immunogenic Cell Death in Lymphoma Cells []
Frontiers in Cell and Developmental Biology Aberrant Expression of High Mobility Group Box Protein 1 in the Idiopathic Inflammatory Myopathies []
Naja sumatrana venom cytotoxin, sumaCTX exhibits concentration-dependent cytotoxicity via caspase-activated mitochondrial-mediated apoptosis without … []
Journal of Burn Care & Research Umbilical cord mesenchymal stem cells (hUCMSCs) for inflammatory regulation after excision and grafting of severe burn wounds in rats [33313794]
Cell Death & Disease DAMPs released by pyroptotic cells as major contributors and therapeutic targets for CAR-T-related toxicities [33504767]
Cells Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death [32331368]
Infect Immun A non-lethal murine flame burn model leads to a transient reduction in host defenses and enhanced susceptibility to lethal Pseudomonas aeruginosa infection [34152806]
Inhaled [D-Ala2]-Dynorphin 1-6 Prevents Hyperacetylation and Release of High Mobility Group Box 1 in a Mouse Model of Acute Lung Injury [34616852]
Mol Cell Biochem Autophagy-associated HMGB-1 as a novel potential circulating non-invasive diagnostic marker for detection of Urothelial Carcinoma of Bladder [34796446]
World J Gastroenterol Calycosin attenuates severe acute pancreatitis-associated acute lung injury by curtailing high mobility group box 1-induced inflammation [34908806]
Endocr J Clinical significance of high mobility group box 1/toll-like receptor 4 in obese diabetic patients [34657898]
Research in Veterinary Science Choline or CDP-choline restores hypotension and improves myocardial and respiratory functions in dogs with experimentally–Induced endotoxic shock [34715589]
Sci Rep Intracellular translocation of HMGB1 is important for Zika virus replication in Huh7 cells [Pubmed:35058496]
ORL J Otorhinolaryngol Relat Spec High Mobility Group Box-1 Protein and Interleukin 33 Expression in Allergic Rhinitis [Pubmed:34979505]
J Exp Clin Cancer Res SKP2 drives the sensitivity to neddylation inhibitors and cisplatin in malignant pleural mesothelioma [Pubmed:35197103]
Am J Physiol Gastrointest Liver Physiol Abnormal intestinal milieu in post-traumatic stress disorder is not impacted by treatment that improves symptoms [Pubmed:35638693]
Journal of the South African Veterinary Association Circulating markers of endothelial activation in canine parvoviral enteritis []
Reseach square The antiviral action of resveratrol against Zika virus through the regulation of interferon responses by HMGB1 []
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