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粘蛋白5AC(MUC5AC)多克隆抗体

Polyclonal Antibody to Mucin 5 Subtype AC (MUC5AC)

TBM; MUC5; LeB; Oligomeric Mucus/Gel-Forming; Mucin 5,Subtypes A And C,Tracheobronchial/Gastric; Gastric mucin; Lewis B blood group antigen; Major airway glycoprotein

  • 粘蛋白5AC(MUC5AC)多克隆抗体 产品包装(模拟)
  • 粘蛋白5AC(MUC5AC)多克隆抗体 产品包装(模拟)
  • 粘蛋白5AC(MUC5AC)多克隆抗体 IHC图
  • PAA756Mu03.jpg Figure. Western Blot; Sample: Recombinant MUC5AC, Mouse.
  • Certificate 通过ISO 9001、ISO 13485质量体系认证

特异性

该抗体是针对MUC5AC的兔多克隆抗体。在免疫组织化学染色和免疫印迹实验中能识别MUC5AC。

用法

Western blotting: 0.5-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

储存

经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。

稳定性

热稳定性以损失率显示。损失率是由加速降解试验决定,具体方法如下:在37°C孵育48小时,没有显著的降解或者沉淀产生。保质期内,在适当的条件下存储,损失率低于5%。

赠品

相关产品

编号 适用物种:Mus musculus (Mouse,小鼠) 应用(仅供研究使用,不用于临床诊断!)
RPA756Mu02 粘蛋白5AC(MUC5AC)重组蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
RPA756Mu01 粘蛋白5AC(MUC5AC)重组蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
RPA756Mu03 粘蛋白5AC(MUC5AC)重组蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
PAA756Mu01 粘蛋白5AC(MUC5AC)多克隆抗体 WB; IHC; ICC; IP.
PAA756Mu02 粘蛋白5AC(MUC5AC)多克隆抗体 WB; IHC; ICC; IP.
PAA756Mu03 粘蛋白5AC(MUC5AC)多克隆抗体 WB; IHC; ICC; IP.
LAA756Mu81 粘蛋白5AC(MUC5AC)多克隆抗体(异硫氰酸荧光素标记) WB; IHC; ICC; IF.
LAA756Mu71 粘蛋白5AC(MUC5AC)多克隆抗体(生物素标记) WB; IHC; ICC.
IEA756Mu 粘蛋白5AC(MUC5AC)检测试剂盒(酶联免疫吸附试验法,快捷型) Enzyme-linked immunosorbent assay for Antigen Detection.
SEA756Mu 粘蛋白5AC(MUC5AC)检测试剂盒(酶联免疫吸附试验法) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA756Mu 粘蛋白5AC(MUC5AC)检测试剂盒(化学发光免疫分析法) Chemiluminescent immunoassay for Antigen Detection.
LMA756Mu 粘蛋白5AC(MUC5AC)等多因子检测试剂盒(流式荧光发光法) FLIA Kit for Antigen Detection.
KSA756Mu01 粘蛋白5AC(MUC5AC)检测试剂盒DIY材料(酶联免疫吸附试验法) Main materials for "Do It (ELISA Kit) Yourself".

参考文献

杂志 参考文献
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Cell & Molecular Biology Role of aquaporin 5 in antigen-induced airway inflammation and mucous hyperproduction in mice [PubMed: 20550619]
Mucosal Immunology Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13 [Nature: 201082a]
European Journal of Pharmacology Naringin attenuates EGF-induced MUC5AC secretion in A549 cells by suppressing the cooperative activities of MAPKs-AP-1 and IKKs-IκB-NF-κB signaling pathways [ScienceDirect: S0014299912005523]
PLoS One Baicalein Reduces Airway Injury in Allergen and IL-13 Induced Airway Inflammation [PubMed: PMC3639905]
Respiratory Researh Pyocyanin-induced mucin production is associated with redox modification of FOXA2 [PubMed: PMC3765780]
Surgery A novel serum marker for biliary tract cancer: Diagnostic and prognostic values of quantitative evaluation of serum mucin 5AC (MUC5AC) [Pubmed: 24468034]
Biochemical and Biophysical Research Communications The human cathelicidin LL-37 enhances airway mucus production in chronic obstructive pulmonary disease [Pubmed:24291709]
Journal of Proteomics Proteomic analysis of cancer and mesothelial cells reveals an increase in Mucin 5AC during ovarian cancer and peritoneal interaction [Pubmed:24726482]
Experimental Lung Research The human Cathelicidin LL-37 induces MUC5AC mucin production by airway epithelial cells via TACE-TGF-α-EGFR pathway [Pubmed:24901072]
Surgery.? Assessment of bile and serum mucin5AC in cholangiocarcinoma: Diagnostic performance and biologic significance [Pubmed:25151557]
Allergology International Leukotriene E 4 induces MUC5AC release from human airway epithelial NCI-H292 cells [Pubmed:25838093]
Respirology Secreted mucins and airway bacterial colonization in non-CF bronchiectasis [PubMed: 26172851]
S Isabela Casagrande Jeremias [Teses: Disponiveis]
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Deletion Polymorphism and Chronic Obstructive Pulmonary Disease ReCavia (Guinea pig )lation of Viral Infection-induced Airway Remodeling Cytokine Production by the TLR3-EGFR Signaling Pathway in Human Bronchial Epithelial Cells [Pubmed:27075970]
Int J Clin Exp Med The influence of long-term corneal contact lens wearing on the stability and quality of tear film in Qinghai [files:ijcem0020163.pdf]
Ann Am Thorac Soc Airway Mucin 2 Is Decreased in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization [doi:10.1513]
Sci Rep Impact of Cigarette Smoking on Tear Function and Correlation between Conjunctival Goblet Cells and Tear MUC5AC Concentration in Office Workers [Pubmed:27297822]
Cytokine. Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasalepithelial cells. [pubmed:27776277]
J Virol.  Mutating the CX3C Motif in the G Protein Should Make a Live Respiratory Syncytial Virus Vaccine Safer and More Effective. [pubmed:28275196]
Respiratory Physiology & Neurobiology Peroxiredoxin 6 suppresses Muc5ac overproduction in LPS-induced airway inflammation through H2O2-EGFR-MAPK signaling pathway. [pubmed:27884794]
Journal of Immunology Research Beneficial effects of prebiotic Saccharomyces cerevisiae mannan on allergic asthma mouse models [pubmed:28835901]
BASIC INVESTIGATION Efficacy of Sodium Hyaluronate in Murine Diabetic Ocular Surface Diseases [pubmed:28644234]
International Immunopharmacology Clarithromycin inhibits TNF-α-induced MUC5AC mucin gene expression via the MKP-1-p38MAPK-dependent pathway [pubmed:28550735]
Секреторно-экссудативная реакция слизистой носа на воздействие холодного воздуха у больных бронхиальной астмой [10.20538/1682-0363-2017-2-146-158]
Cellular Microbiology An adherent mucus layer attenuates the genotoxic effect of colibactin. [pubmed:29156489]
Respiratory Research IL-4-induced caveolin-1-containing lipid rafts aggregation contributes to MUC5AC synthesis in bronchial epithelial cells [pubmed:28931396]
Chemotherapy Oxytetracycline Inhibits Mucus Secretion and Inflammation in Human Airway Epithelial Cells. [pubmed:28578323]
Allergy Th2 cytokines orchestrate the secretion of MUC 5 AC and MUC 5B in IL‐5 positive chronic rhinosinusitis with nasal polyps [Pubmed:29802623]
European Journal of Pharmacology  Salvianolic acid B improves airway hyperresponsiveness by inhibiting MUC5AC overproduction associated with Erk1/2/P38 signaling [Pubmed:29382534]
Inflammation Plantamajoside Inhibits Lipopolysaccharide-Induced MUC5AC Expression and Inflammation through Suppressing the PI3K/Akt and NF-κB Signaling Pathways in … [Pubmed:29349683]
Pulmonary Pharmacology and Therapeutics In vivo and in vitro investigation of anti-inflammatory and mucus-regulatory activities of a fixed combination of thyme and primula extracts [Pubmed:29698781]
European Respiratory Society Profiling of healthy and asthmatic airway smooth muscle cells following IL-1β treatment: a novel role for CCL20 in chronic mucus hyper-secretion [Pubmed:29946002]
Clinical and Experimental Ophthalmology Development of a highly sensitive and reliable enzyme-linked immunosorbent assay for MUC5aC in human tears extracted from schirmer strips [Pubmed: 30214141]
international journal of biological macromolecules Increased expression of long non-coding RNA SNHG16 correlates with tumor progression and poor prognosis in non-small cell lung cancer [Pubmed: 30287374]
Journal of Investigative Medicine The characteristics and clinical significance of mucin levels in bronchoalveolar lavage fluid of patients with interstitial lung disease [Pubmed: 30573494]
Phytomedicine Regulation effects of naringin on diesel particulate matter-induced abnormal airway surface liquid secretion [Pubmed: 31301536]
Scientific Reports Regional comparison of Goblet cell number and Area in exposed and covered Dry eyes and their Correlation with Tear MUC5AC [Pubmed: 32076085]
Eur J Pharmacol TLR3 inhibitor and tyrosine kinase inhibitor attenuate cigarette smoke/poly I: C-induced airway inflammation and remodeling by the EGFR/TLR3/MAPK … [Pubmed: 33068589]
journal of ethnopharmacology Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K … [Pubmed: 32344236]
Less Airway Inflammation and Goblet Cell Metaplasia in an IL-33-Induced Asthma Model of Leptin-Deficient Obese Mice []
Exp Mol Pathol The regulatory role of SFRP5/WNT5A axis in allergic rhinitis through inhibiting JNK pathway activation and lowering mucin generation in human nasal?¡­ [33285209]
FEBS Open Bio Porphyromonas gingivalis gingipains potentially affect MUC5AC gene expression and protein levels in respiratory epithelial cells [33332733]
Cell Rep Generation of functional conjunctival epithelium, including goblet cells, from human iPSCs [33535050]
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